Repository logo
 
Publication

Tolerogenic insulin peptide therapy precipitates type 1 diabetes

2017-05-23Journal article Open access
Simple item page
dc.contributor.authorBergman, Marie-Louise
dc.contributor.authorLopes-Carvalho, Thiago
dc.contributor.authorMartins, Ana-Catarina
dc.contributor.authorGrieco, Fabio A.
dc.contributor.authorEizirik, Décio L.
dc.contributor.authorDemengeot, Jocelyne
dc.date.accessioned2017-12-11T14:54:38Z
dc.date.available2017-12-11T14:54:38Z
dc.date.issued2017-05-23
dc.descriptionThe deposited article version contains attached the supplementary materials within the pdf.pt_PT
dc.description.abstractDaniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.pt_PT
dc.description.sponsorshipEuropean Union’s (EU FP7) Large-Scale Focused Collaborative Research Project on Natural Immunomodulators as Novel Immunotherapies for Type 1 Diabetes grant: (NAIMIT, 241447).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTolerogenic insulin peptide therapy precipitates type 1 diabetes Marie-Louise Bergman, Thiago Lopes-Carvalho, Ana-Catarina Martins, Fabio A. Grieco, Décio L. Eizirik, Jocelyne Demengeot Journal of Experimental Medicine Jul 2017, 214 (7) 2153-2156; DOI: 10.1084/jem.20160471pt_PT
dc.identifier.doi10.1084/jem.20160471pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/820
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.publisherRockefeller University Presspt_PT
dc.relationNovel immunotherapies for type 1 diabetes.
dc.relation.publisherversionhttp://jem.rupress.org/content/214/7/2153.longpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectAutoantibodiespt_PT
dc.subjectDiabetes Mellitus, Type 1pt_PT
dc.subjectFemalept_PT
dc.subjectHyperglycemiapt_PT
dc.subjectInsulinpt_PT
dc.subjectInsulin Antibodiespt_PT
dc.subjectMice, Inbred NODpt_PT
dc.subjectMicroscopy, Fluorescencept_PT
dc.subjectVaccinationpt_PT
dc.subjectEpitopespt_PT
dc.subjectAutoimmunitypt_PT
dc.titleTolerogenic insulin peptide therapy precipitates type 1 diabetespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNovel immunotherapies for type 1 diabetes.
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/241447/EU
oaire.citation.endPage2156pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage2153pt_PT
oaire.citation.titleJournal of Experimental Medicinept_PT
oaire.citation.volume214pt_PT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationaa295658-7788-4d22-80ef-b389ea280ea8
relation.isProjectOfPublication.latestForDiscoveryaa295658-7788-4d22-80ef-b389ea280ea8

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Demengeot_J.Exp.Med.(2017).pdf
Size:
1.57 MB
Format:
Adobe Portable Document Format
Description:
main article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

LP - Artigos