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Novel insights into mitotic chromosome condensation
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| artigo principal | 2.41 MB | Adobe PDF |
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Orientador(es)
Resumo(s)
The fidelity of mitosis is essential for life, and successful completion of this process relies on drastic changes in chromosome organization at the onset of nuclear division. The mechanisms that govern chromosome compaction at every cell division cycle are still far from full comprehension, yet recent studies provide novel insights into this problem, challenging classical views on mitotic chromosome assembly. Here, we briefly introduce various models for chromosome assembly and known factors involved in the condensation process (e.g. condensin complexes and topoisomerase II). We will then focus on a few selected studies that have recently brought novel insights into the mysterious way chromosomes are condensed during nuclear division.
Descrição
Palavras-chave
mitotic chromosome chromosome condensation
Contexto Educativo
Citação
Piskadlo E and Oliveira RA. Novel insights into mitotic chromosome condensation [version 1; referees: 2 approved]. F1000Research 2016, 5(F1000 Faculty Rev):1807 (doi: 10.12688/f1000research.8727.1)
Editora
F1000Research