Novel insights into mitotic chromosome condensation

Piskadlo, Ewa; Oliveira, Raquel A.

http://hdl.handle.net/10400.7/687

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Authors

Piskadlo, Ewa

Oliveira, Raquel A.

Abstract(s)

The fidelity of mitosis is essential for life, and successful completion of this process relies on drastic changes in chromosome organization at the onset of nuclear division. The mechanisms that govern chromosome compaction at every cell division cycle are still far from full comprehension, yet recent studies provide novel insights into this problem, challenging classical views on mitotic chromosome assembly. Here, we briefly introduce various models for chromosome assembly and known factors involved in the condensation process (e.g. condensin complexes and topoisomerase II). We will then focus on a few selected studies that have recently brought novel insights into the mysterious way chromosomes are condensed during nuclear division.

Keywords

mitotic chromosome chromosome condensation

URI

http://hdl.handle.net/10400.7/687

Citation

Piskadlo E and Oliveira RA. Novel insights into mitotic chromosome condensation [version 1; referees: 2 approved]. F1000Research 2016, 5(F1000 Faculty Rev):1807 (doi: 10.12688/f1000research.8727.1)