Publication
A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration
| dc.contributor.author | Quirk, MC | |
| dc.contributor.author | Sosulski, DL | |
| dc.contributor.author | Feierstein, CE | |
| dc.contributor.author | Uchida, N | |
| dc.contributor.author | Mainen, ZF | |
| dc.date.accessioned | 2010-08-05T10:35:43Z | |
| dc.date.available | 2010-08-05T10:35:43Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons isolated in rat OFC using extracellular waveform and spike train analysis. During performance of a goal-directed behavioral task, the firing of this class of putative fast-spiking (FS) interneurons showed robust temporal correlations indicative of a functionally coherent network. FS cell activity also co-varied with behavioral response latency, a key indicator of motivational state. Systemic administration of ketamine, a drug that can mimic psychosis, preferentially inhibited this cell class. Together, these results support the idea that OFC-FS interneurons form a critical link in the regulation of motivation by prefrontal circuits during normal and abnormal brain and behavioral states. | pt |
| dc.identifier.citation | Quirk, Michael C., Sosulski, Dara L., Feierstein, Claudia E., Naoshige, U., Mainen, Zachary F. (2009). “A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration”. Frontiers in Systems Neuroscience. 3: 1-13 | pt |
| dc.identifier.issn | 1662-5137 | |
| dc.identifier.uri | http://hdl.handle.net/10400.7/145 | |
| dc.language.iso | eng | pt |
| dc.publisher | Cold Spring Harbor | pt |
| dc.title | A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration | pt |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 13 | pt |
| oaire.citation.startPage | 1 | pt |
| oaire.citation.title | Frontiers in Systems Neuroscience | pt |
| rcaap.rights | openAccess | pt |
| rcaap.type | article | pt |