dc.contributor.author	Dalko, Esther
dc.contributor.author	Das, Bidyut
dc.contributor.author	Herbert, Fabien
dc.contributor.author	Fesel, Constantin
dc.contributor.author	Pathak, Sulabha
dc.contributor.author	Tripathy, Rina
dc.contributor.author	Cazenave, Pierre-André
dc.contributor.author	Ravindran, Balachandran
dc.contributor.author	Sharma, Shobhona
dc.contributor.author	Pied, Sylviane
dc.date.accessioned	2016-06-13T15:30:39Z
dc.date.available	2016-06-13T15:30:39Z
dc.date.issued	2015-07-03
dc.description.abstract	Several immunomodulatory factors are involved in malaria pathogenesis. Among them, heme has been shown to play a role in the pathophysiology of severe malaria in rodents, but its role in human severe malaria remains unclear. Circulating levels of total heme and its main scavenger, hemopexin, along with cytokine/chemokine levels and biological parameters, including hemoglobin and creatinine levels, as well as transaminase activities, were measured in the plasma of 237 Plasmodium falciparum-infected patients living in the state of Odisha, India, where malaria is endemic. All patients were categorized into well-defined groups of mild malaria, cerebral malaria (CM), or severe noncerebral malaria, which included acute renal failure (ARF) and hepatopathy. Our results show a significant increase in total plasma heme levels with malaria severity, especially for CM and malarial ARF. Spearman rank correlation and canonical correlation analyses have shown a correlation between total heme, hemopexin, interleukin-10, tumor necrosis factor alpha, gamma interferon-induced protein 10 (IP-10), and monocyte chemotactic protein 1 (MCP-1) levels. In addition, canonical correlations revealed that heme, along with IP-10, was associated with the CM pathophysiology, whereas both IP-10 and MCP-1 together with heme discriminated ARF. Altogether, our data indicate that heme, in association with cytokines and chemokines, is involved in the pathophysiology of both CM and ARF but through different mechanisms.	pt_PT
dc.description.sponsorship	Indo-French Centre for the Promotion of Advanced Research; Associated International Laboratory Systems; Immunology and Genetics of Infectious Diseases; Department of Biotechnology from the Ministry of Science and Technology of India; Tata Institute of Fundamental Research intramural funds; Université Lille 1 (doctoral contract); IFCPAR (Raman-Charpak award); College Doctoral Lille Nord de France (AAP n10 award); Fondation des Treilles; Conseil Régional du Nord-Pas de Calais.	pt_PT
dc.identifier.citation	Multifaceted Role of Heme during Severe Plasmodium falciparum Infections in India Esther Dalko, Bidyut Das, Fabien Herbert, Constantin Fesel, Sulabha Pathak, Rina Tripathy, Pierre-André Cazenave, Balachandran Ravindran, Shobhona Sharma, and Sylviane Pied Infect. Immun. October 2015 83:10 3793-3799; Accepted manuscript posted online 13 July 2015, doi:10.1128/IAI.00531-15	pt_PT
dc.identifier.doi	10.1128/IAI.00531-15	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/642
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	American Society for Microbiology	pt_PT
dc.relation.publisherversion	http://iai.asm.org/content/83/10/3793.long	pt_PT
dc.subject	Adult	pt_PT
dc.subject	Chemokine CCL2	pt_PT
dc.subject	Disease Progression	pt_PT
dc.subject	Female	pt_PT
dc.subject	Heme	pt_PT
dc.subject	Hemopexin	pt_PT
dc.subject	Humans	pt_PT
dc.subject	India	pt_PT
dc.subject	Interleukin-10	pt_PT
dc.subject	Malaria, Falciparum	pt_PT
dc.subject	Male	pt_PT
dc.subject	Middle Aged	pt_PT
dc.subject	Plasmodium falciparum	pt_PT
dc.subject	Tumor Necrosis Factor-alpha	pt_PT
dc.subject	Young Adult	pt_PT
dc.title	Multifaceted Role of Heme during Severe Plasmodium falciparum Infections in India	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	3799	pt_PT
oaire.citation.issue	10	pt_PT
oaire.citation.startPage	3793	pt_PT
oaire.citation.title	Infection and Immunity	pt_PT
oaire.citation.volume	83	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT

Multifaceted Role of Heme during Severe Plasmodium falciparum Infections in India

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