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Tolerogenic insulin peptide therapy precipitates type 1 diabetes

2017-05-23Review Open access
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dc.contributor.authorBergman, Marie-Louise
dc.contributor.authorLopes-Carvalho, Thiago
dc.contributor.authorMartins, Ana-Catarina
dc.contributor.authorGrieco, Fabio A.
dc.contributor.authorEizirik, Décio L.
dc.contributor.authorDemengeot, Jocelyne
dc.date.accessioned2017-12-07T16:27:54Z
dc.date.available2017-12-07T16:27:54Z
dc.date.issued2017-05-23
dc.descriptionThis deposit is composed by the main article plus the supplementary materials of the publication.pt_PT
dc.description.abstractDaniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.pt_PT
dc.description.sponsorshipFurther funders are not indicated in the document.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTolerogenic insulin peptide therapy precipitates type 1 diabetes Marie-Louise Bergman, Thiago Lopes-Carvalho, Ana-Catarina Martins, Fabio A. Grieco, Décio L. Eizirik, Jocelyne Demengeot Journal of Experimental Medicine Jul 2017, 214 (7) 2153-2156; DOI: 10.1084/jem.20160471pt_PT
dc.identifier.doi10.1084/jem.20160471pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/819
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRockefeller University Presspt_PT
dc.relationNovel immunotherapies for type 1 diabetes.
dc.relation.publisherversionhttp://jem.rupress.org/content/214/7/2153pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectAutoimmunitypt_PT
dc.subjectdiabetespt_PT
dc.subjectinsulinpt_PT
dc.subjectVaccinationpt_PT
dc.titleTolerogenic insulin peptide therapy precipitates type 1 diabetespt_PT
dc.typereview
dspace.entity.typePublication
oaire.awardTitleNovel immunotherapies for type 1 diabetes.
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/241447/EU
oaire.citation.endPage2156pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage2153pt_PT
oaire.citation.titleJournal of Experimental Medicinept_PT
oaire.citation.volume214pt_PT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typereviewpt_PT
relation.isProjectOfPublicationaa295658-7788-4d22-80ef-b389ea280ea8
relation.isProjectOfPublication.latestForDiscoveryaa295658-7788-4d22-80ef-b389ea280ea8

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