Repository logo
 
Publication

Multiple domain insertions and losses in the evolution of the Rab prenylation complex

2007-08Journal article Open access
Simple item page
dc.contributor.authorRasteiro, R.
dc.contributor.authorPereira Leal, J.B.
dc.date.accessioned2009-10-17T11:35:58Z
dc.date.available2009-10-17T11:35:58Z
dc.date.issued2007-08
dc.description.abstractBACKGROUND: Rab proteins are regulators of vesicular trafficking, requiring a lipid modification for proper function, prenylation of C-terminal cysteines. This is catalysed by a complex of a catalytic heterodimer (Rab Geranylgeranyl Transferase - RabGGTase) and an accessory protein (Rab Escort Protein. REP). Components of this complex display domain insertions relative to paralogous proteins. The function of these inserted domains is unclear. RESULTS: We profiled the domain architecture of the components of the Rab prenylation complex in evolution. We identified the orthologues of the components of the Rab prenylation machinery in 43 organisms, representing the crown eukaryotic groups. We characterize in detail the domain structure of all these components and the phylogenetic relationships between the individual domains. CONCLUSION: We found different domain insertions in different taxa, in alpha-subunits of RGGTase and REP. Our results suggest that there were multiple insertions, expansions and contractions in the evolution of this prenylation complexpt
dc.identifier.citationRasteiro, R., Pereira-Leal, J.B. (2007). "Multiple domain insertions and losses in the evolution of the Rab prenylation complex". BMC Evolutionary Biology. 7:140pt
dc.identifier.issn1471-2148
dc.identifier.urihttp://hdl.handle.net/10400.7/59
dc.language.isoengpt
dc.subjectProtein Prenylationpt
dc.subjectProtein Structure, Tertiarypt
dc.subjectrab GTP-Binding Proteins/geneticspt
dc.subjectGene Duplicationpt
dc.subjectEvolution, Molecularpt
dc.subjectAlkyl and Aryl Transferases/geneticspt
dc.titleMultiple domain insertions and losses in the evolution of the Rab prenylation complexpt
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage140pt
oaire.citation.titleBMC Evolutionary Biologypt
rcaap.rightsopenAccesspt
rcaap.typearticlept

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
00482.pdf
Size:
609.81 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CG - Artigos