dc.contributor.author	Paulo, Tânia F.
dc.contributor.author	Nolte, Viola
dc.contributor.author	Schlötterer, Christian
dc.contributor.author	Sucena, Élio
dc.contributor.author	Teixeira, Luis
dc.date.accessioned	2016-10-10T15:15:29Z
dc.date.available	2016-10-10T15:15:29Z
dc.date.issued	2016-09-29
dc.description.abstract	Microbial symbionts can modulate host interactions with biotic and abiotic factors. Such interactions may affect the evolutionary trajectories of both host and symbiont. Wolbachia protects Drosophila melanogaster against several viral infections and the strength of the protection varies between variants of this endosymbiont. Since Wolbachia is maternally transmitted, its fitness depends on the fitness of its host. Therefore, Wolbachia populations may be under selection when Drosophila is subjected to viral infection. Here we show that in D. melanogaster populations selected for increased survival upon infection with Drosophila C virus there is a strong selection coefficient for specific Wolbachia variants, leading to their fixation. Flies carrying these selected Wolbachia variants have higher survival and fertility upon viral infection when compared to flies with the other variants. These findings demonstrate how the interaction of a host with pathogens shapes the genetic composition of symbiont populations. Furthermore, host adaptation can result from the evolution of its symbionts, with host and symbiont functioning as a single evolutionary unit.	pt_PT
dc.description.sponsorship	Austrian Science Funds grant: (FWF P27630).	pt_PT
dc.identifier.citation	Faria VG, Martins NE, PauloTF, Magalhães S, NolteV, Schlötte rer C, et al. (2016) Drosophila Adaptati on to Viral Infection through Defensive Symbiont Evolution. PLoS Genet 12(9): e1006297. doi:10.1371 /journal. pgen.1006297	pt_PT
dc.identifier.doi	10.1371/journal.pgen.1006297	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/699
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Public Library of Science	pt_PT
dc.relation	EVOLUTION OF THE IMMUNE RESPONSE OF DROSOPHILA MELANOGASTER: INSIGHTS USING EXPERIMENTAL EVOLUTION TO MULTIPLE PATHOGENS AND EXPOSURE SCENARIOS
dc.relation.publisherversion	http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006297	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Wolbachia	pt_PT
dc.subject	Host-pathogen interactions	pt_PT
dc.subject	Drosophila melanogaster	pt_PT
dc.subject	Viral evolution	pt_PT
dc.subject	Viral transmission and infection	pt_PT
dc.subject	Parasite evolution	pt_PT
dc.subject	Natural selection	pt_PT
dc.subject	Microbial evolution	pt_PT
dc.title	Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	EVOLUTION OF THE IMMUNE RESPONSE OF DROSOPHILA MELANOGASTER: INSIGHTS USING EXPERIMENTAL EVOLUTION TO MULTIPLE PATHOGENS AND EXPOSURE SCENARIOS
oaire.awardURI	info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F82299%2F2011/PT
oaire.awardURI	info:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F62964%2F2009/PT
oaire.awardURI	info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-MII%2F105655%2F2008/PT
oaire.citation.endPage	18	pt_PT
oaire.citation.issue	9	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	PLoS Genetics	pt_PT
oaire.citation.volume	12	pt_PT
oaire.fundingStream	SFRH
oaire.fundingStream	3599-PPCDT
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
project.funder.name	Fundação para a Ciência e a Tecnologia
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isProjectOfPublication	ac14821e-d799-459e-83a4-da88e7da795d
relation.isProjectOfPublication	41fc5436-eb50-4a62-9c43-d97ef6402690
relation.isProjectOfPublication	ba0bda37-baec-46f3-ac2b-11b2dcd28e3f
relation.isProjectOfPublication.latestForDiscovery	41fc5436-eb50-4a62-9c43-d97ef6402690

Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution

Files

Original bundle

License bundle

Collections