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Genetics of host-parasite interactions: towards a comprehensive dissection of Drosophila resistance to viral infection

2016-10-07Journal article Open access
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dc.contributor.authorMagalhães, Sara
dc.contributor.authorSucena, Élio
dc.date.accessioned2017-11-02T17:47:57Z
dc.date.available2017-11-02T17:47:57Z
dc.date.issued2016-10-07
dc.descriptionThe deposited article is a post-print version and has peer-review. There are no funders and sponsors indicated explicitly in the document. There is no public supplementary material available. This publication hasn't any creative commons license associated.pt_PT
dc.description.abstractOne of the major challenges in evolutionary biology is to unravel the genetic basis of adaptation. This issue has been gaining momentum in recent years with the accelerated development of novel genetic and genomic techniques and resources. In this issue of Molecular Ecology, Cogni et al. (2016) address the genetic basis of resistance to two viruses in Drosophila melanogaster using a panel of recombinant inbred lines with unprecedented resolution allowing detection of rare alleles and/or alleles of small effect. The study confirms the role of previously identified genes of major effect and adds novel regions with minor effect to the genetic basis of Drosophila resistance to the Drosophila C virus or the sigma virus. Additional analyses reveal the absence of cross-resistance and of epistasis between the various genomic regions. This detailed information on the genetic architecture of host resistance constitutes an important step towards the understanding of both the physiology of antiviral immunity and the evolution of host-parasite interactions.pt_PT
dc.description.sponsorshipThere are no funders and sponsors indicated explicitly in this uploaded article version.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMagalhães, S. and Sucena, É. (2016), Genetics of host–parasite interactions: towards a comprehensive dissection of Drosophila resistance to viral infection. Mol Ecol, 25: 4981–4983. doi:10.1111/mec.13834pt_PT
dc.identifier.doi10.1111/mec.13834pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/797
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationThere are no funders and sponsors indicated explicitly in the document.pt_PT
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/mec.13834/abstractpt_PT
dc.subjectadaptationpt_PT
dc.subjectgenomics/proteomicspt_PT
dc.subjecthost-parasite interactionspt_PT
dc.subjectinsectspt_PT
dc.subjectquantitative geneticspt_PT
dc.titleGenetics of host-parasite interactions: towards a comprehensive dissection of Drosophila resistance to viral infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4983pt_PT
oaire.citation.issue20pt_PT
oaire.citation.startPage4981pt_PT
oaire.citation.titleMolecular Ecologypt_PT
oaire.citation.volume25pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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