Brain Transcriptomic Response to Social Eavesdropping in Zebrafish (Danio rerio)

Lopes, João Sollari; Abril-de-Abreu, Rodrigo; Oliveira, Rui F.

Publication

Brain Transcriptomic Response to Social Eavesdropping in Zebrafish (Danio rerio)

2015-12-29Journal article

dc.contributor.author	Lopes, João Sollari
dc.contributor.author	Abril-de-Abreu, Rodrigo
dc.contributor.author	Oliveira, Rui F.
dc.date.accessioned	2016-01-07T17:51:09Z
dc.date.available	2016-01-07T17:51:09Z
dc.date.issued	2015-12-29
dc.description.abstract	Public information is widely available at low cost to animals living in social groups. For instance, bystanders may eavesdrop on signaling interactions between conspecifics and use it to adapt their subsequent behavior towards the observed individuals. This social eavesdropping ability is expected to require specialized mechanisms such as social attention, which selects social information available for learning. To begin exploring the genetic basis of social eavesdropping, we used a previously established attention paradigm in the lab to study the brain gene expression profile of male zebrafish (Danio rerio) in relation to the attention they paid towards conspecifics involved or not involved in agonistic interactions. Microarray gene chips were used to characterize their brain transcriptomes based on differential expression of single genes and gene sets. These analyses were complemented by promoter region-based techniques. Using data from both approaches, we further drafted protein interaction networks. Our results suggest that attentiveness towards conspecifics, whether interacting or not, activates pathways linked to neuronal plasticity and memory formation. The network analyses suggested that fos and jun are key players on this response, and that npas4a, nr4a1 and egr4 may also play an important role. Furthermore, specifically observing fighting interactions further triggered pathways associated to a change in the alertness status (dnajb5) and to other genes related to memory formation (btg2, npas4b), which suggests that the acquisition of eavesdropped information about social relationships activates specific processes on top of those already activated just by observing conspecifics.	pt_PT
dc.description.sponsorship	FCT PhD fellowship: (SFRH/BD/33280/2007), Champalimaud Neuroscience Programme, FCT research grant: (PTDC/PSI-PCO/118776/2010).	pt_PT
dc.identifier.citation	Lopes JS, Abril-de-Abreu R, Oliveira RF (2015) Brain Transcriptomic Response to Social Eavesdropping in Zebrafish ( Danio rerio ). PLoS ONE 10(12): e0145801. doi:10.1371/journal.pone.0145801	pt_PT
dc.identifier.doi	10.1371/journal.pone.0145801	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/546
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	PLOS	pt_PT
dc.relation	Molecular mechanisms and evolutionary implications of social plasticity
dc.relation.publisherversion	http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145801	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Gene expression	pt_PT
dc.subject	Transcriptome analysis	pt_PT
dc.subject	Zebrafish	pt_PT
dc.subject	Animal sociality	pt_PT
dc.subject	Animal behavior	pt_PT
dc.subject	Genetic networks	pt_PT
dc.subject	Transcription factors	pt_PT
dc.subject	Network motifs	pt_PT
dc.title	Brain Transcriptomic Response to Social Eavesdropping in Zebrafish (Danio rerio)	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	Molecular mechanisms and evolutionary implications of social plasticity
oaire.awardURI	info:eu-repo/grantAgreement/FCT/3599-PPCDT/EXCL%2FBIA-ANM%2F0549%2F2012/PT
oaire.citation.endPage	21	pt_PT
oaire.citation.issue	12	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	PLOS One	pt_PT
oaire.citation.volume	10	pt_PT
oaire.fundingStream	3599-PPCDT
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isProjectOfPublication	82059d0f-2e10-410d-9df7-0253285a858c
relation.isProjectOfPublication.latestForDiscovery	82059d0f-2e10-410d-9df7-0253285a858c