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Brain Transcriptomic Response to Social Eavesdropping in Zebrafish (Danio rerio)

dc.contributor.authorLopes, João Sollari
dc.contributor.authorAbril-de-Abreu, Rodrigo
dc.contributor.authorOliveira, Rui F.
dc.date.accessioned2016-01-07T17:51:09Z
dc.date.available2016-01-07T17:51:09Z
dc.date.issued2015-12-29
dc.description.abstractPublic information is widely available at low cost to animals living in social groups. For instance, bystanders may eavesdrop on signaling interactions between conspecifics and use it to adapt their subsequent behavior towards the observed individuals. This social eavesdropping ability is expected to require specialized mechanisms such as social attention, which selects social information available for learning. To begin exploring the genetic basis of social eavesdropping, we used a previously established attention paradigm in the lab to study the brain gene expression profile of male zebrafish (Danio rerio) in relation to the attention they paid towards conspecifics involved or not involved in agonistic interactions. Microarray gene chips were used to characterize their brain transcriptomes based on differential expression of single genes and gene sets. These analyses were complemented by promoter region-based techniques. Using data from both approaches, we further drafted protein interaction networks. Our results suggest that attentiveness towards conspecifics, whether interacting or not, activates pathways linked to neuronal plasticity and memory formation. The network analyses suggested that fos and jun are key players on this response, and that npas4a, nr4a1 and egr4 may also play an important role. Furthermore, specifically observing fighting interactions further triggered pathways associated to a change in the alertness status (dnajb5) and to other genes related to memory formation (btg2, npas4b), which suggests that the acquisition of eavesdropped information about social relationships activates specific processes on top of those already activated just by observing conspecifics.pt_PT
dc.description.sponsorshipFCT PhD fellowship: (SFRH/BD/33280/2007), Champalimaud Neuroscience Programme, FCT research grant: (PTDC/PSI-PCO/118776/2010).pt_PT
dc.identifier.citationLopes JS, Abril-de-Abreu R, Oliveira RF (2015) Brain Transcriptomic Response to Social Eavesdropping in Zebrafish ( Danio rerio ). PLoS ONE 10(12): e0145801. doi:10.1371/journal.pone.0145801pt_PT
dc.identifier.doi10.1371/journal.pone.0145801pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/546
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLOSpt_PT
dc.relationMolecular mechanisms and evolutionary implications of social plasticity
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145801pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGene expressionpt_PT
dc.subjectTranscriptome analysispt_PT
dc.subjectZebrafishpt_PT
dc.subjectAnimal socialitypt_PT
dc.subjectAnimal behaviorpt_PT
dc.subjectGenetic networkspt_PT
dc.subjectTranscription factorspt_PT
dc.subjectNetwork motifspt_PT
dc.titleBrain Transcriptomic Response to Social Eavesdropping in Zebrafish (Danio rerio)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMolecular mechanisms and evolutionary implications of social plasticity
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXCL%2FBIA-ANM%2F0549%2F2012/PT
oaire.citation.endPage21pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePLOS Onept_PT
oaire.citation.volume10pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication82059d0f-2e10-410d-9df7-0253285a858c
relation.isProjectOfPublication.latestForDiscovery82059d0f-2e10-410d-9df7-0253285a858c

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