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The Ol1mpiad: concordance of behavioural faculties of stage 1 and stage 3 Drosophila larvae.

2017-07-05Journal article Open access
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dc.contributor.authorAlmeida-Carvalho, Maria J.
dc.contributor.authorBerh, Dimitri
dc.contributor.authorBraun, Andreas
dc.contributor.authorChen, Yi-chun
dc.contributor.authorEichler, Katharina
dc.contributor.authorEschbach, Claire
dc.contributor.authorFritsch, Pauline M. J.
dc.contributor.authorGerber, Bertram
dc.contributor.authorHoyer, Nina
dc.contributor.authorJiang, Xiaoyi
dc.contributor.authorKleber, Jörg
dc.contributor.authorKlämbt, Christian
dc.contributor.authorKönig, Christian
dc.contributor.authorLouis, Matthieu
dc.contributor.authorMichels, Birgit
dc.contributor.authorMiroschnikow, Anton
dc.contributor.authorMirth, Christen
dc.contributor.authorMiura, Daisuke
dc.contributor.authorNiewalda, Thomas
dc.contributor.authorOtto, Nils
dc.contributor.authorPaisios, Emmanouil
dc.contributor.authorPankratz, Michael J.
dc.contributor.authorPetersen, Meike
dc.contributor.authorRamsperger, Noel
dc.contributor.authorRandel, Nadine
dc.contributor.authorRisse, Benjamin
dc.contributor.authorSaumweber, Timo
dc.contributor.authorSchlegel, Philipp
dc.contributor.authorSchleyer, Michael
dc.contributor.authorSoba, Peter
dc.contributor.authorSprecher, Simon G.
dc.contributor.authorTanimura, Teiichi
dc.contributor.authorThum, Andreas S.
dc.contributor.authorToshima, Naoko
dc.contributor.authorTruman, Jim W.
dc.contributor.authorYarali, Ayse
dc.contributor.authorZlatic, Marta
dc.date.accessioned2017-07-13T14:08:43Z
dc.date.available2018-07-05T00:30:08Z
dc.date.issued2017-07-05
dc.descriptionThis publication hasn't any creative commons license associated. This article has a Company of Biologists User Licence 1.1. The deposited article version contains attached the supplementary materials within the pdf.pt_PT
dc.description.abstractMapping brain function to brain structure is a fundamental task for neuroscience. For such an endeavour, the Drosophila larva is simple enough to be tractable, yet complex enough to be interesting. It features about 10,000 neurons and is capable of various taxes, kineses and Pavlovian conditioning. All its neurons are currently being mapped into a light-microscopical atlas, and Gal4 strains are being generated to experimentally access neurons one at a time. In addition, an electron microscopic reconstruction of its nervous system seems within reach. Notably, this electron microscope-based connectome is being drafted for a stage 1 larva - because stage 1 larvae are much smaller than stage 3 larvae. However, most behaviour analyses have been performed for stage 3 larvae because their larger size makes them easier to handle and observe. It is therefore warranted to either redo the electron microscopic reconstruction for a stage 3 larva or to survey the behavioural faculties of stage 1 larvae. We provide the latter. In a community-based approach we called the Ol1mpiad, we probed stage 1 Drosophila larvae for free locomotion, feeding, responsiveness to substrate vibration, gentle and nociceptive touch, burrowing, olfactory preference and thermotaxis, light avoidance, gustatory choice of various tastants plus odour-taste associative learning, as well as light/dark-electric shock associative learning. Quantitatively, stage 1 larvae show lower scores in most tasks, arguably because of their smaller size and lower speed. Qualitatively, however, stage 1 larvae perform strikingly similar to stage 3 larvae in almost all cases. These results bolster confidence in mapping brain structure and behaviour across developmental stages.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia grants: (SFRH/BPD/75993/2011EXPL/BEX-BID/0497/2013); Cluster of Excellence Cells in Motion; CiM International Max Planck research school; Spanish Ministry of Economy and Competitiveness; ‘Centro de Excelencia Severo Ochoa 2013-2017’ grant: (SEV-2012-0208); CERCA Programme/Generalitat de Catalunya; the ‘la Caixa’ International PhD Programme; Spanish Ministry of Science and Innovation grant: (BFU2011-26208); Wissenschaftsgemeinschaft Gottfried Wilhelm Leibniz; State of Sachsen-Anhalt; Center for Behavioral Brain Sciences Magdeburg; Otto von Guericke Universität Magdeburg; Deutsche Forschungsgemeinschaft grants: (CRC 779 Motivated behaviour: B11; GE1091/4-1, SPP 1926, Next generation optogenetics, SO1337/2-1, CRC 779 Motivated behaviour: B15; YA272/2-1, PA 787/7-1, (TH1584/1-1, TH1584/3-1); European Commission grant: (FP7-ICT project Miniature Insect Model for Active Learning MINIMAL); Howard Hughes Medical Institute; European Research Council grant: (ERC-2012-StG 309832-PhotoNaviNet); Swiss National Science Foundation grant: (31003A_169993); Landesforschungsförderung Hamburg grant: (LFF-FV27); Wissenschaftsgemeinschaft Gottfried Wilhelm Leibniz; State of Sachsen-Anhalt; Center for Behavioral Brain Sciences Magdeburg; Cluster of Excellence ImmunoSensation; Baden-Württemberg Stiftung; Zukunftskolleg of the University of Konstanz.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlmeida-Carvalho, M. J., Berh, D., Braun, A., Chen, Y.-C., Eichler, K., Eschbach, C., Fritsch, P. M. J., Gerber, B., Hoyer, N., Jiang, X., et al. (2017). The Ol1mpiad: concordance of behavioural faculties of stage 1 and stage 3 Drosophila larvae. J. Exp. Biol. 220, 2452–2475.pt_PT
dc.identifier.doi10.1242/jeb.156646pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/776
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCompany of Biologistspt_PT
dc.relationSEV-2012-0208pt_PT
dc.relationBFU2011-26208pt_PT
dc.relationDevelopmental mechanisms underlying the ontogeny of foraging behaviour in fruit fly larvae
dc.relation31003A_169993pt_PT
dc.relationMiniature Insect Model for Active Learning
dc.relationPhotoreception in Drosophila larvae: Information coding in a simple neuronal circuit
dc.relationCRC 779 Motivated behaviour: B15; YA272/2-1pt_PT
dc.relationPA 787/7-1pt_PT
dc.relationTH1584/1-1pt_PT
dc.relationTH1584/3-1pt_PT
dc.relation.publisherversionhttp://jeb.biologists.org/content/220/13/2452.longpt_PT
dc.subjectSensory processingpt_PT
dc.subjectLocomotionpt_PT
dc.subjectFeedingpt_PT
dc.subjectLearning and memorypt_PT
dc.subjectNavigationpt_PT
dc.titleThe Ol1mpiad: concordance of behavioural faculties of stage 1 and stage 3 Drosophila larvae.pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopmental mechanisms underlying the ontogeny of foraging behaviour in fruit fly larvae
oaire.awardTitleMiniature Insect Model for Active Learning
oaire.awardTitlePhotoreception in Drosophila larvae: Information coding in a simple neuronal circuit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F75993%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FBEX-BID%2F0497%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/618045/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/309832/EU
oaire.citation.endPage2475pt_PT
oaire.citation.issue13pt_PT
oaire.citation.startPage2452pt_PT
oaire.citation.titleJournal of Experimental Biologypt_PT
oaire.citation.volume220pt_PT
oaire.fundingStreamSFRH
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFP7
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
rcaap.embargofctThe deposited article has 12 months of embargo period in terms of access, because of the journal's policies and the publisher's copyright policy, which require a period of embargo of 12 months.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication050fd846-5c77-40d1-854d-8c3e9d1b2b61
relation.isProjectOfPublication2b02c411-894e-42ce-be36-3735179b76a5
relation.isProjectOfPublication429e142c-b906-4d91-84de-d1fd5b0a8e1c
relation.isProjectOfPublication16d51882-7164-4495-be5e-567949e1b036
relation.isProjectOfPublication.latestForDiscovery050fd846-5c77-40d1-854d-8c3e9d1b2b61

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