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Beyond killing: Can we find new ways to manage infection?

2016-03-25Journal article Open access
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dc.contributor.authorVale, Pedro F.
dc.contributor.authorMcNally, Luke
dc.contributor.authorDoeschl-Wilson, Andrea
dc.contributor.authorKing, Kayla C.
dc.contributor.authorPopat, Roman
dc.contributor.authorDomingo-Sananes, Maria R.
dc.contributor.authorAllen, Judith E.
dc.contributor.authorSoares, Miguel P.
dc.contributor.authorKümmerli, Rolf
dc.date.accessioned2017-05-25T14:42:02Z
dc.date.available2017-05-25T14:42:02Z
dc.date.issued2016-03-25
dc.descriptionThis deposit is composed by the main article, and hasn't not associated any supplementary materials of the publication.pt_PT
dc.description.abstractThe antibiotic pipeline is running dry and infectious disease remains a major threat to public health. An efficient strategy to stay ahead of rapidly adapting pathogens should include approaches that replace, complement or enhance the effect of both current and novel antimicrobial compounds. In recent years, a number of innovative approaches to manage disease without the aid of traditional antibiotics and without eliminating the pathogens directly have emerged. These include disabling pathogen virulence-factors, increasing host tissue damage control or altering the microbiota to provide colonization resistance, immune resistance or disease tolerance against pathogens. We discuss the therapeutic potential of these approaches and examine their possible consequences for pathogen evolution. To guarantee a longer half-life of these alternatives to directly killing pathogens, and to gain a full understanding of their population-level consequences, we encourage future work to incorporate evolutionary perspectives into the development of these treatments.pt_PT
dc.description.sponsorshipWellcome Trust for the Centre for Immunity, Infection and Evolution grant: (095831); ETH Zürich fellowship: (Society in Science—Branco Weiss); Human Frontier Science Programme grant: (HFSP RGP0011/2014); Fundação Calouste Gulbenkian; Fundação para a Ciência e Tecnologia grants: (PTDC/SAU TOX/116627/2010, HMSP-ICT/0022/2010); ERC 7th Framework grant: (ERC-2011-AdG.294709-DAMAGECONTROL); BSRC Institute Strategic Programme grant: (ISP1); Swiss National Science Foundation grant: (PP00P3-139164); Novartis Foundation for medical and biological research.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPedro F. Vale, Luke McNally, Andrea Doeschl-Wilson, Kayla C. King, Roman Popat, Maria R. Domingo-Sananes, Judith E. Allen, Miguel P. Soares, Rolf Kümmerli; Beyond killing: Can we find new ways to manage infection?. Evol Med Public Health 2016; 2016 (1): 148-157. doi: 10.1093/emph/eow012pt_PT
dc.identifier.doi10.1093/emph/eow012pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/760
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relationHFSP RGP0011/2014pt_PT
dc.relationHMSP-ICT/0022/2010pt_PT
dc.relationPP00P3-139164pt_PT
dc.relationTissue Damage Control Regulates The Pathogenesis of Immune Mediated Inflammatory Diseases
dc.relation.publisherversionhttps://academic.oup.com/emph/article-lookup/doi/10.1093/emph/eow012pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectinfectionpt_PT
dc.subjectanti-virulence drugspt_PT
dc.subjectdamage limitationpt_PT
dc.subjectdisease tolerancept_PT
dc.subjectmicrobiotapt_PT
dc.subjectevolutionpt_PT
dc.titleBeyond killing: Can we find new ways to manage infection?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTissue Damage Control Regulates The Pathogenesis of Immune Mediated Inflammatory Diseases
oaire.awardURIinfo:eu-repo/grantAgreement/WT/Immunology and Infectious Disease/095831
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-TOX%2F116627%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/294709/EU
oaire.citation.endPage157pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage148pt_PT
oaire.citation.titleEvolution, Medicine, and Public Healthpt_PT
oaire.citation.volume2016pt_PT
oaire.fundingStreamImmunology and Infectious Disease
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/100010269
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameWellcome Trust
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication3ca52bdd-758e-48d5-8237-3a52f267c018
relation.isProjectOfPublication72d8fa6f-1215-4a61-bc70-515eef334d45
relation.isProjectOfPublication370f9aad-c4ef-4e35-b754-edc840dc6b5e
relation.isProjectOfPublication.latestForDiscovery3ca52bdd-758e-48d5-8237-3a52f267c018

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