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Determinants of the Sympatric Host-Pathogen Relationship in Tuberculosis

2015-11-03Journal article Open access
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dc.contributor.authorDavid, Susana
dc.contributor.authorMateus, A. R. A.
dc.contributor.authorDuarte, Elsa L.
dc.contributor.authorAlbuquerque, José
dc.contributor.authorPortugal, Clara
dc.contributor.authorSancho, Luísa
dc.contributor.authorLavinha, João
dc.contributor.authorGonçalves, Guilherme
dc.date.accessioned2015-11-17T15:25:27Z
dc.date.available2015-11-17T15:25:27Z
dc.date.issued2015-11-03
dc.description.abstractMajor contributions from pathogen genome analysis and host genetics have equated the possibility of Mycobacterium tuberculosis co-evolution with its human host leading to more stable sympatric host-pathogen relationships. However, the attribution to either sympatric or allopatric categories depends on the resolution or grain of genotypic characterization. We explored the influence on the sympatric host-pathogen relationship of clinical (HIV infection and multidrug-resistant tuberculosis [MDRTB]) and demographic (gender and age) factors in regards to the genotypic grain by using spacer oligonucleotide typing (spoligotyping) for classification of M. tuberculosis strains within the Euro-American lineage. We analyzed a total of 547 tuberculosis (TB) cases, from six year consecutive sampling in a setting with high TB-HIV coinfection (32.0%). Of these, 62.0% were caused by major circulating pathogen genotypes. The sympatric relationship was defined according to spoligotype in comparison to the international spoligotype database SpolDB4. While no significant association with Euro-American lineage was observed with any of the factors analyzed, increasing the resolution with spoligotyping evidenced a significant association of MDRTB with sympatric strains, regardless of the HIV status. Furthermore, distribution curves of the prevalence of sympatric and allopatric TB in relation to patients' age showed an accentuation of the relevance of the age of onset in the allopatric relationship, as reflected in the trimodal distribution. On the contrary, sympatric TB was characterized by the tendency towards a typical (standard) distribution curve. Our results suggest that within the Euro-American lineage a greater degree of genotyping fine-tuning is necessary in modeling the biological processes behind the host-pathogen interplay. Furthermore, prevalence distribution of sympatric TB to age was suggestive of host genetic determinisms driven by more common variants.pt_PT
dc.description.sponsorshipLuso-American Development Foundation: (LACR Award program - 2007), European Community fund: (FEDER).pt_PT
dc.identifier.citationDavid S, Mateus ARA, Duarte EL, Albuquerque J, Portugal C, Sancho L, et al. (2015) Determinants of the Sympatric Host-Pathogen Relationship in Tuberculosis. PLoS ONE 10(11): e0140625. doi:10.1371/journal.pone.0140625pt_PT
dc.identifier.doi10.1371/journal.pone.0140625pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/497
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLOSpt_PT
dc.relationSearch for inhibitors of the D-ala-D-ala pathway in peptidoglycan synthesis as potential anti-tuberculosis drugs
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140625pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTuberculosispt_PT
dc.subjectMycobacterium tuberculosispt_PT
dc.subjectHost-pathogen interactionspt_PT
dc.subjectHIV infectionspt_PT
dc.subjectPhylogeographypt_PT
dc.subjectAge groupspt_PT
dc.subjectHIVpt_PT
dc.subjectPortugalpt_PT
dc.titleDeterminants of the Sympatric Host-Pathogen Relationship in Tuberculosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSearch for inhibitors of the D-ala-D-ala pathway in peptidoglycan synthesis as potential anti-tuberculosis drugs
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCTI%2FESP%2F44826%2F2002/PT
oaire.citation.endPage18pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePLOS Onept_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamPOCI
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication0442737d-3002-4170-afd2-7a4d8719712f
relation.isProjectOfPublication.latestForDiscovery0442737d-3002-4170-afd2-7a4d8719712f

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