dc.contributor.author	Alves, Joao M.
dc.contributor.author	Lima, Ana C.
dc.contributor.author	Pais, Isa A.
dc.contributor.author	Amir, Nadir
dc.contributor.author	Celestino, Ricardo
dc.contributor.author	Piras, Giovanna
dc.contributor.author	Monne, Maria
dc.contributor.author	Comas, David
dc.contributor.author	Heutink, Peter
dc.contributor.author	Chikhi, Lounès
dc.contributor.author	Amorim, António
dc.contributor.author	Lopes, Alexandra M.
dc.date.accessioned	2016-11-29T18:24:31Z
dc.date.available	2016-11-29T18:24:31Z
dc.date.issued	2015-11-11	pt
dc.description.abstract	A polymorphic inversion that lies on chromosome 17q21 comprises two major haplotype families (H1 and H2) that not only differ in orientation but also in copy-number. Although the processes driving the spread of the inversion-associated lineage (H2) in humans remain unclear, a selective advantage has been proposed for one of its subtypes. Here, we genotyped a large panel of individuals from previously overlooked populations using a custom array with a unique panel of H2-specific single nucleotide polymorphisms and found a patchy distribution of H2 haplotypes in Africa, with North Africans displaying a higher frequency of inverted subtypes, when compared with Sub-Saharan groups. Interestingly, North African H2s were found to be closer to "non-African" chromosomes further supporting that these populations may have diverged more recently from groups outside Africa. Our results uncovered higher diversity within the H2 family than previously described, weakening the hypothesis of a strong selective sweep on all inverted chromosomes and suggesting a rather complex evolutionary history at this locus.	pt_PT
dc.description.sponsorship	FEDER funds: (Operational Programme for Competitiveness Factors—COMPETE); Fundação para a Ciência e a Tecnologia grants: (IF/01262/2014); Programa Operacional Regional do Norte grants: (NORTE-07-0162-FEDER-00018, NORTE-07-0162-FEDER-000067); Quadro de Referência Estratégica Nacional (QREN); EMBO short-term fellowship: (ASFT 520-2013); Spanish MINECO project: (CGL2013-44351-P); Laboratoire d’Excellence (LABEX) TULIP:(ANR-10-LABX-41).	pt_PT
dc.identifier.citation	Joao M. Alves, Ana C. Lima, Isa A. Pais, Nadir Amir, Ricardo Celestino, Giovanna Piras, Maria Monne, David Comas, Peter Heutink, Lounès Chikhi, António Amorim, and Alexandra M. Lopes Reassessing the Evolutionary History of the 17q21 Inversion Polymorphism Genome Biol Evol (2015) Vol. 7 3239-3248 first published online November 11, 2015 doi:10.1093/gbe/evv214	pt_PT
dc.identifier.doi	10.1093/gbe/evv214	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/722
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Oxford University Press	pt_PT
dc.relation	A vertebrate's eye view on habitat loss and fragmentation across time and space in Madagascar
dc.relation.publisherversion	http://gbe.oxfordjournals.org/content/7/12/3239	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	chromosomal inversions	pt_PT
dc.subject	human demography	pt_PT
dc.subject	human evolution	pt_PT
dc.title	Reassessing the Evolutionary History of the 17q21 Inversion Polymorphism	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	A vertebrate's eye view on habitat loss and fragmentation across time and space in Madagascar
oaire.awardURI	info:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FSAU%2FLA0003%2F2013/PT
oaire.awardURI	info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F51004%2F2010/PT
oaire.awardURI	info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F51695%2F2011/PT
oaire.awardURI	info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-BIC%2F4476%2F2012/PT
oaire.citation.endPage	3248	pt_PT
oaire.citation.issue	12	pt_PT
oaire.citation.startPage	3239	pt_PT
oaire.citation.title	Genome Biology and Evolution	pt_PT
oaire.citation.volume	7	pt_PT
oaire.fundingStream	COMPETE
oaire.fundingStream	SFRH
oaire.fundingStream	SFRH
oaire.fundingStream	3599-PPCDT
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
project.funder.name	Fundação para a Ciência e a Tecnologia
project.funder.name	Fundação para a Ciência e a Tecnologia
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isProjectOfPublication	b9938442-7f53-4f7b-8b4c-cf23ea7e07ce
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Reassessing the Evolutionary History of the 17q21 Inversion Polymorphism

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