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Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats

2015-12-11Journal article Open access
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dc.contributor.authorCascão, Rita
dc.contributor.authorVidal, Bruno
dc.contributor.authorLopes, Inês P.
dc.contributor.authorPaisana, Eunice
dc.contributor.authorRino, José
dc.contributor.authorMoita, Luis F.
dc.contributor.authorFonseca, João E.
dc.date.accessioned2015-12-21T16:38:17Z
dc.date.available2015-12-21T16:38:17Z
dc.date.issued2015-12-11
dc.description.abstractRheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease characterized by cellular infiltration into the joints, hyperproliferation of synovial cells and bone damage. Available treatments for RA only induce remission in around 30% of the patients, have important adverse effects and its use is limited by their high cost. Therefore, compounds that can control arthritis, with an acceptable safety profile and low production costs are still an unmet need. We have shown, in vitro, that celastrol inhibits both IL-1β and TNF, which play an important role in RA, and, in vivo, that celastrol has significant anti-inflammatory properties. Our main goal in this work was to test the effect of celastrol in the number of sublining CD68 macrophages (a biomarker of therapeutic response for novel RA treatments) and on the overall synovial tissue cellularity and joint structure in the adjuvant-induced rat model of arthritis (AIA).pt_PT
dc.description.sponsorshipFCT fellowship: (SFRH/BPD/92860/2013).pt_PT
dc.identifier.citationCascão R, Vidal B, Lopes IP, Paisana E, Rino J, Moita LF, et al. (2015) Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats. PLoS ONE 10(12): e0142448. doi:10.1371/journal.pone.0142448pt_PT
dc.identifier.doi10.1371/journal.pone.0142448pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/536
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLOSpt_PT
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142448pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectArthritispt_PT
dc.subjectMacrophagespt_PT
dc.subjectInflammationpt_PT
dc.subjectInflammatory diseasespt_PT
dc.subjectCytokinespt_PT
dc.subjectRheumatoid arthritispt_PT
dc.subjectAnklespt_PT
dc.subjectHematoxylin stainingpt_PT
dc.titleDecrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage18pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePLOS Onept_PT
oaire.citation.volume10pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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