A3.6 Two components contributing to reduced treg surface CD25 in sle patients and their unaffected relatives

Background FOXP3+ regulatory T-cells (Tregs) in Systemic Lupus Erythematosus (SLE) are in a functionally deficient state with a characteristic reduction or absence of surface CD25 (the IL-2 receptor alpha chain). Genetic variation in the CD25-encoding IL2RA locus is associated with other autoimmune disorders.

Keywords

Systemic Lupus Erythematosus (SLE) CD25 FOXP3+

URI

http://hdl.handle.net/10400.7/677

Citation

A3.6 Two components contributing to reduced treg surface CD25 in sle patients and their unaffected relatives N Costa, O Marques, S Godinho, C Carvalho, B Leal, C Vasconcelos, A Marinho, M F Moraes-Fontes, A Gomes da Costa, C Ponte, R Marques, T Coias, A R Martins, J F Viana, B Martins, C Fesel Ann Rheum Dis 2014;73:Suppl 1 A44 doi:10.1136/annrheumdis-2013-205124.100