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Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation

2016-02-29Journal article Open access
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dc.contributor.authorKoyama, Takashi
dc.contributor.authorMirth, Christen K.
dc.date.accessioned2016-03-07T13:13:44Z
dc.date.available2016-03-07T13:13:44Z
dc.date.issued2016-02-29
dc.description.abstractIn Drosophila, the fat body, functionally equivalent to the mammalian liver and adipocytes, plays a central role in regulating systemic growth in response to nutrition. The fat body senses intracellular amino acids through Target of Rapamycin (TOR) signaling, and produces an unidentified humoral factor(s) to regulate insulin-like peptide (ILP) synthesis and/or secretion in the insulin-producing cells. Here, we find that two peptides, Growth-Blocking Peptide (GBP1) and CG11395 (GBP2), are produced in the fat body in response to amino acids and TOR signaling. Reducing the expression of GBP1 and GBP2 (GBPs) specifically in the fat body results in smaller body size due to reduced growth rate. In addition, we found that GBPs stimulate ILP secretion from the insulin-producing cells, either directly or indirectly, thereby increasing insulin and insulin-like growth factor signaling activity throughout the body. Our findings fill an important gap in our understanding of how the fat body transmits nutritional information to the insulin producing cells to control body size.pt_PT
dc.description.sponsorshipFCT fellowship: (SFRH/BPD/74313/2010); Fundação Calouste Gulbenkian.pt_PT
dc.identifier.citationKoyama T, Mirth CK (2016) Growth- Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation. PLoS Biol 14(2): e1002392. doi:10.1371/journal. pbio.1002392pt_PT
dc.identifier.doi10.1371/journal.pbio.1002392pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/556
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLOSpt_PT
dc.relation.publisherversionhttp://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002392pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFatspt_PT
dc.subjectLarvaept_PT
dc.subjectTOR signalingpt_PT
dc.subjectPhysiological parameterspt_PT
dc.subjectInsulin secretionpt_PT
dc.subjectDrosophila melanogasterpt_PT
dc.subjectSignal peptidespt_PT
dc.subjectNutritionpt_PT
dc.titleGrowth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage23pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePlos Biologypt_PT
oaire.citation.volume14pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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