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Adaptive immunity increases the pace and predictability of evolutionary change in commensal gut bacteria

2015-11-30Journal article Open access
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dc.contributor.authorBarroso-Batista, João
dc.contributor.authorDemengeot, Jocelyne
dc.contributor.authorGordo, Isabel
dc.date.accessioned2015-12-07T17:22:02Z
dc.date.available2015-12-07T17:22:02Z
dc.date.issued2015-11-30
dc.description.abstractCo-evolution between the mammalian immune system and the gut microbiota is believed to have shaped the microbiota's astonishing diversity. Here we test the corollary hypothesis that the adaptive immune system, directly or indirectly, influences the evolution of commensal species. We compare the evolution of Escherichia coli upon colonization of the gut of wild-type and Rag2(-/-) mice, which lack lymphocytes. We show that bacterial adaptation is slower in immune-compromised animals, a phenomenon explained by differences in the action of natural selection within each host. Emerging mutations exhibit strong beneficial effects in healthy hosts but substantial antagonistic pleiotropy in immune-deficient mice. This feature is due to changes in the composition of the gut microbiota, which differs according to the immune status of the host. Our results indicate that the adaptive immune system influences the tempo and predictability of E. coli adaptation to the mouse gut.pt_PT
dc.description.sponsorshipEU-FP7 infrastructure grants: (EMMA and InfrafrontierI3), LAO/ITQB, FCT grant: (SFRH/BD/80257/2011).pt_PT
dc.identifier.citationBarroso-Batista, J. et al. Adaptive immunity increases the pace and predictability of evolutionary change in commensal gut bacteria. Nat. Commun. 6:8945 doi: 10.1038/ncomms9945 (2015).pt_PT
dc.identifier.doi10.1038/ncomms9945pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/529
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Publishing Grouppt_PT
dc.relationMicrobial adaptation within ecosystems
dc.relationAdaptation of commensal bacteria to the mammalian gut
dc.relation.publisherversionhttp://www.nature.com/ncomms/2015/151130/ncomms9945/full/ncomms9945.htmlpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiological sciencespt_PT
dc.subjectEvolutionpt_PT
dc.subjectGeneticspt_PT
dc.subjectMicrobiologypt_PT
dc.titleAdaptive immunity increases the pace and predictability of evolutionary change in commensal gut bacteriapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMicrobial adaptation within ecosystems
oaire.awardTitleAdaptation of commensal bacteria to the mammalian gut
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/260421/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-EVF%2F118075%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/RECI%2FIMI-IMU%2F0038%2F2012/PT
oaire.citation.endPage13pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleNature Communicationspt_PT
oaire.citation.volume6pt_PT
oaire.fundingStreamFP7
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication1f01df05-f8af-4e76-8dec-0fc6237b41fd
relation.isProjectOfPublication8a096e46-5521-429a-b9e8-8a7901fe8b30
relation.isProjectOfPublication1470c3e4-1d23-40cc-9500-9f8843b0e35d
relation.isProjectOfPublication.latestForDiscovery8a096e46-5521-429a-b9e8-8a7901fe8b30

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