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Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide

2003-02-17Journal article Open access
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dc.contributor.authorCaramalho, I.
dc.contributor.authorLopes-Carvalho, T.
dc.contributor.authorOstler, D.
dc.contributor.authorZelenay, S.
dc.contributor.authorHaury, M
dc.contributor.authorDemengeot, J
dc.date.accessioned2010-08-11T13:06:12Z
dc.date.available2010-08-11T13:06:12Z
dc.date.issued2003-02-17
dc.description.abstractRegulatory CD4 T cells (Treg) control inflammatory reactions to commensal bacteria and opportunist pathogens. Activation of Treg functions during these processes might be mediated by host-derived proinflammatory molecules or directly by bacterial products. We tested the hypothesis that engagement of germline-encoded receptors expressed by Treg participate in the triggering of their function. We report that the subset of CD4 cells known to exert regulatory functions in vivo (CD45RB(low) CD25(+)) selectively express Toll-like receptors (TLR)-4, -5, -7, and -8. Exposure of CD4(+) CD25(+) cells to the TLR-4 ligand lipopolysaccharide (LPS) induces up-regulation of several activation markers and enhances their survival/proliferation. This proliferative response does not require antigen-presenting cells and is augmented by T cell receptor triggering and interleukin 2 stimulation. Most importantly, LPS treatment increases CD4(+) CD25(+) cell suppressor efficiency by 10-fold and reveals suppressive activity in the CD4(+) CD45RB(low) CD25(-) subset that when tested ex-vivo, scores negative. Moreover, LPS-activated Treg efficiently control naive CD4 T cell-dependent wasting disease. These findings provide the first evidence that Treg respond directly to proinflammatory bacterial products, a mechanism that likely contributes to the control of inflammatory responsespt
dc.identifier.citationCaramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. (2003). “Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide”. Journal of Experimental Medicine. 197 (4): 403-411pt
dc.identifier.urihttp://hdl.handle.net/10400.7/161
dc.language.isoengpt
dc.publisherRockfeller University Presspt
dc.subjectInflammationpt
dc.subjectTolerancept
dc.subjectLymphocytespt
dc.subjectRegulationpt
dc.subjectInnate immunitypt
dc.titleRegulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharidept
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage411pt
oaire.citation.startPage403pt
oaire.citation.titleJournal of Experimental Medicinept
rcaap.rightsopenAccesspt
rcaap.typearticlept

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