Conflict between heterozygote advantage and hybrid incompatibility in haplodiploids (and sex chromosomes)

Ghenu, Ana-Hermina; Blanckaert, Alexandre; Butlin, Roger K.; Kulmuni, Jonna; Bank, Claudia

Publication

Conflict between heterozygote advantage and hybrid incompatibility in haplodiploids (and sex chromosomes)

2018Journal article

dc.contributor.author	Ghenu, Ana-Hermina
dc.contributor.author	Blanckaert, Alexandre
dc.contributor.author	Butlin, Roger K.
dc.contributor.author	Kulmuni, Jonna
dc.contributor.author	Bank, Claudia
dc.date.accessioned	2018-01-29T16:17:36Z
dc.date.available	2019-01-01T01:30:07Z
dc.date.issued	2018
dc.description	The deposited article version is a post-print and is the "Accepted Author Manuscript" provided by Wiley and posted online on 12th January 2018.	pt_PT
dc.description	This publication hasn't any creative commons license associated.	pt_PT
dc.description	This deposit is composed by the main article plus the supplementary materials of the publication.	pt_PT
dc.description.abstract	In many diploid species the sex chromosomes play a special role in mediating reproductive isolation. In haplodiploids, where females are diploid and males haploid, the whole genome behaves similarly to the X/Z chromosomes of diploids. Therefore, haplodiploid systems can serve as a model for the role of sex chromosomes in speciation and hybridization. A previously described population of Finnish Formica wood ants displays genome-wide signs of ploidally and sexually antagonistic selection resulting from hybridization. Here, hybrid females have increased survivorship but hybrid males are inviable. To understand how the unusual hybrid population may be maintained, we developed a mathematical model with hybrid incompatibility, female heterozygote advantage, recombination, and assortative mating. The rugged fitness landscape resulting from the co-occurrence of heterozygote advantage and hybrid incompatibility results in a sexual conflict in haplodiploids, which is caused by the ploidy difference. Thus, whereas heterozygote advantage always promotes long-term polymorphism in diploids, we find various outcomes in haplodiploids in which the population stabilizes either in favor of males, females, or via maximizing the number of introgressed individuals. We discuss these outcomes with respect to the potential long-term fate of the Finnish wood ant population, and provide approximations for the extension of the model to multiple incompatibilities. Moreover, we highlight the general implications of our results for speciation and hybridization in haplodiploids versus diploids, and how the described fitness relationships could contribute to the outstanding role of sex chromosomes as hotspots of sexual antagonism and genes involved in speciation. This article is protected by copyright. All rights reserved.	pt_PT
dc.description.sponsorship	Fundação Calouste Gulbenkian; National Science Foundation grant: (NSF PHY-1125915); Human Frontier Science Program; Finnish Cultural Foundation; Academy of Finland grant: (252411).	pt_PT
dc.description.version	info:eu-repo/semantics/acceptedVersion	pt_PT
dc.identifier.citation	Ghenu, A.-H., Blanckaert, A., Butlin, R. K., Kulmuni, J. and Bank, C. (), Conflict between heterozygote advantage and hybrid incompatibility in haplodiploids (and sex chromosomes). Mol Ecol. Accepted Author Manuscript. doi:10.1111/mec.14482	pt_PT
dc.identifier.doi	10.1111/mec.14482	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/825
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Wiley	pt_PT
dc.relation	NSF PHY-1125915	pt_PT
dc.relation	252411	pt_PT
dc.relation.publisherversion	http://onlinelibrary.wiley.com/doi/10.1111/mec.14482/abstract?systemMessage=Please+be+advised+that+we+experienced+an+unexpected+issue+that+occurred+on+Saturday+and+Sunday+January+20th+and+21st+that+caused+the+site+to+be+down+for+an+extended+period+of+time+and+affected+the+ability+of+users+to+access+content+on+Wiley+Online+Library.+This+issue+has+now+been+fully+resolved.++We+apologize+for+any+inconvenience+this+may+have+caused+and+are+working+to+ensure+that+we+can+alert+you+immediately+of+any+unplanned+periods+of+downtime+or+disruption+in+the+future.	pt_PT
dc.subject	Hybridization	pt_PT
dc.subject	heterosis	pt_PT
dc.subject	epistasis	pt_PT
dc.subject	haplodiploidy	pt_PT
dc.subject	ﬁtness landscape	pt_PT
dc.subject	speciation	pt_PT
dc.title	Conflict between heterozygote advantage and hybrid incompatibility in haplodiploids (and sex chromosomes)	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	27	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	Molecular Ecology	pt_PT
rcaap.embargofct	The deposited article has 13 months of embargo period in terms of access, because of the journal's policies and the publisher's copyright policy, which require a period of embargo of 12 months after the date of the publication, and since the article hasn't been published it has a extended date of embargo, as a preventive measure.	pt_PT
rcaap.rights	embargoedAccess	pt_PT
rcaap.type	article	pt_PT