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Myocardial aging as a T-cell–mediated phenomenon

2017-03Journal article Open access
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dc.contributor.authorRamos, Gustavo Campos
dc.contributor.authorvan den Berg, Anne
dc.contributor.authorNunes-Silva, Vânia
dc.contributor.authorWeirather, Johannes
dc.contributor.authorPeters, Laura
dc.contributor.authorBurkard, Matthias
dc.contributor.authorFriedrich, Mike
dc.contributor.authorPinnecker, Jürgen
dc.contributor.authorAbeßer, Marco
dc.contributor.authorHeinze, Katrin G.
dc.contributor.authorSchuh, Kai
dc.contributor.authorBeyersdorf, Niklas
dc.contributor.authorKerkau, Thomas
dc.contributor.authorJocelyne, Demengeot
dc.contributor.authorFrantz, Stefan
dc.contributor.authorHofmann, Ulrich
dc.date.accessioned2020-03-30T10:02:33Z
dc.date.available2020-03-30T10:02:33Z
dc.date.issued2017-03
dc.description.abstractIn recent years, the myocardium has been rediscovered under the lenses of immunology, and lymphocytes have been implicated in the pathogenesis of cardiomyopathies with different etiologies. Aging is an important risk factor for heart diseases, and it also has impact on the immune system. Thus, we sought to determine whether immunological activity would influence myocardial structure and function in elderly mice. Morphological, functional, and molecular analyses revealed that the age-related myocardial impairment occurs in parallel with shifts in the composition of tissue-resident leukocytes and with an accumulation of activated CD4+ Foxp3- (forkhead box P3) IFN-γ+ T cells in the heart-draining lymph nodes. A comprehensive characterization of different aged immune-deficient mouse strains revealed that T cells significantly contribute to age-related myocardial inflammation and functional decline. Upon adoptive cell transfer, the T cells isolated from the mediastinal lymph node (med-LN) of aged animals exhibited increased cardiotropism, compared with cells purified from young donors or from other irrelevant sites. Nevertheless, these cells caused rather mild effects on cardiac functionality, indicating that myocardial aging might stem from a combination of intrinsic and extrinsic (immunological) factors. Taken together, the data herein presented indicate that heart-directed immune responses may spontaneously arise in the elderly, even in the absence of a clear tissue damage or concomitant infection. These observations might shed new light on the emerging role of T cells in myocardial diseases, which primarily affect the elderly population.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1073/pnas.1621047114pt_PT
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/10400.7/949
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationBundesministerium für Bildung und Forschung (BMBF01 EO1004)pt_PT
dc.relationGerman Research Foundation (DFG SFB688, TP A10, and B07)pt_PT
dc.relationBrazilian National Council for Scientific and Technological Developmentpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAdoptive Transferpt_PT
dc.subjectAgingpt_PT
dc.subjectAnimalspt_PT
dc.subjectCD4-Positive T-Lymphocytespt_PT
dc.subjectHeartpt_PT
dc.subjectHumanspt_PT
dc.subjectLymph Nodespt_PT
dc.subjectMalept_PT
dc.subjectMicept_PT
dc.subjectMice, Inbred C57BLpt_PT
dc.subjectMyocardiumpt_PT
dc.titleMyocardial aging as a T-cell–mediated phenomenonpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPageE2429pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPageE2420pt_PT
oaire.citation.titleProceedings of the National Academy of Sciencespt_PT
oaire.citation.volume114pt_PT
person.familyNameDemengeot
person.givenNameJocelyne
person.identifier21837
person.identifier.ciencia-id3A12-B260-A36C
person.identifier.orcid0000-0002-4761-614X
person.identifier.ridK-8072-2014
person.identifier.scopus-author-id6603702602
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationeda6ec95-9595-42b6-9dfe-078e88d8cb2b
relation.isAuthorOfPublication.latestForDiscoveryeda6ec95-9595-42b6-9dfe-078e88d8cb2b

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