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Evolution of Drosophila resistance against different pathogens and infection routes entails no detectable maintenance costs

2015-11-17Journal article Open access
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dc.contributor.authorFaria, Vítor G.
dc.contributor.authorMartins, Nelson E.
dc.contributor.authorPaulo, Tânia
dc.contributor.authorTeixeira, Luís
dc.contributor.authorSucena, Élio
dc.contributor.authorMagalhães, Sara
dc.date.accessioned2017-11-02T17:31:32Z
dc.date.available2017-11-02T17:31:32Z
dc.date.issued2015-11-17
dc.descriptionThe deposited article is a post-print version and has peer-review. The deposited article version contains attached the supplementary materials within the pdf. This publication hasn't any creative commons license associated.pt_PT
dc.description.abstractPathogens exert a strong selective pressure on hosts, entailing host adaptation to infection. This adaptation often affects negatively other fitness-related traits. Such trade-offs may underlie the maintenance of genetic diversity for pathogen resistance. Trade-offs can be tested with experimental evolution of host populations adapting to parasites, using two approaches: (1) measuring changes in immunocompetence in relaxed-selection lines and (2) comparing life-history traits of evolved and control lines in pathogen-free environments. Here, we used both approaches to examine trade-offs in Drosophila melanogaster populations evolving for over 30 generations under infection with Drosophila C Virus or the bacterium Pseudomonas entomophila, the latter through different routes. We find that resistance is maintained after up to 30 generations of relaxed selection. Moreover, no differences in several classical life-history traits between control and evolved populations were found in pathogen-free environments, even under stresses such as desiccation, nutrient limitation, and high densities. Hence, we did not detect any maintenance costs associated with resistance to pathogens. We hypothesize that extremely high selection pressures commonly used lead to the disproportionate expression of costs relative to their actual occurrence in natural systems. Still, the maintenance of genetic variation for pathogen resistance calls for an explanation.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia grants: (#SFRH/BD/82299/2011, #SFRH/BPD/62964/2009); Instituto Gulbenkian de Ciência; Fundação Calouste Gulbenkian.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFaria, V. G., Martins, N. E., Paulo, T., Teixeira, L., Sucena, É. and Magalhães, S. (2015), Evolution of Drosophila resistance against different pathogens and infection routes entails no detectable maintenance costs. Evolution, 69: 2799–2809. doi:10.1111/evo.12782pt_PT
dc.identifier.doi10.1111/evo.12782pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/796
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationEVOLUTION OF THE IMMUNE RESPONSE OF DROSOPHILA MELANOGASTER: INSIGHTS USING EXPERIMENTAL EVOLUTION TO MULTIPLE PATHOGENS AND EXPOSURE SCENARIOS
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/evo.12782/abstractpt_PT
dc.subjectCostspt_PT
dc.subjectDrosophilapt_PT
dc.subjectexperimental evolutionpt_PT
dc.subjecthost–parasitept_PT
dc.subjectimmunitypt_PT
dc.subjecttrade-offspt_PT
dc.titleEvolution of Drosophila resistance against different pathogens and infection routes entails no detectable maintenance costspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEVOLUTION OF THE IMMUNE RESPONSE OF DROSOPHILA MELANOGASTER: INSIGHTS USING EXPERIMENTAL EVOLUTION TO MULTIPLE PATHOGENS AND EXPOSURE SCENARIOS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F82299%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F62964%2F2009/PT
oaire.citation.endPage2809pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage2799pt_PT
oaire.citation.titleEvolutionpt_PT
oaire.citation.volume69pt_PT
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationac14821e-d799-459e-83a4-da88e7da795d
relation.isProjectOfPublication41fc5436-eb50-4a62-9c43-d97ef6402690
relation.isProjectOfPublication.latestForDiscoveryac14821e-d799-459e-83a4-da88e7da795d

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