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The reinfection threshold regulates pathogen diversity: the case of influenza

2007-02-22Journal article Open access
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dc.contributor.authorGokaydin, D.
dc.contributor.authorOliveira-Martins, J.B.
dc.contributor.authorGordo, I.
dc.contributor.authorGomes, M.G.M.
dc.date.accessioned2010-03-25T11:06:21Z
dc.date.available2010-03-25T11:06:21Z
dc.date.issued2007-02-22
dc.descriptionFor accessing the publication please visit the following link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2358964/pt_PT
dc.description.abstractThe awareness that pathogens can adapt and evolve over relatively short time-scales is changing our view of infectious disease epidemiology and control. Research on the transmission dynamics of antigenically diverse pathogens is progressing and there is increasing recognition for the need of new concepts and theories. Mathematical models have been developed considering the modelling unit in two extreme scales: either diversity is not explicitly represented or diversity is represented at the finest scale of single variants. Here, we use an intermediate approach and construct a model at the scale of clusters of variants. The model captures essential properties of more detailed systems and is much more amenable to mathematical treatment. Specificities of pathogen clusters and the overall potential for transmission determine the reinfection rates. These are, in turn, important regulators of cluster dynamics. Ultimately, we detect a reinfection threshold (RT) that separates different behaviours along the transmissibility axis: below RT, levels of infection are low and cluster substitutions are probable; while above RT, levels of infection are high and multiple cluster coexistence is the most probable outcome.pt
dc.identifier.citationGokaydin D, Oliveira-Martins JB , Gordo I, and MGM Gomes (2007) The reinfection threshold regulates pathogen diversity: the case of influenza. J Roy. Soc. Interface 4(12):137-42pt
dc.identifier.doi10.1098/rsif.2006.0159pt_PT
dc.identifier.issn1742-5662
dc.identifier.urihttp://hdl.handle.net/10400.7/82
dc.language.isoengpt
dc.relation.publisherversionhttp://rsif.royalsocietypublishing.org/content/4/12/137.longpt_PT
dc.subjectAntigenic Variation/genetics/immunologypt
dc.subjectDisease Outbreaks/statistics & numerical datapt
dc.subjectDisease Transmission, Infectious/statistics & numerical datapt
dc.subjectGenetic Variation/geneticspt
dc.subjectInfluenza A virus/genetics/immunologypt
dc.subjectInfluenza, Human/epidemiology/genetics/immunologypt
dc.subjectModels, Immunologicalpt
dc.titleThe reinfection threshold regulates pathogen diversity: the case of influenzapt
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage142pt
oaire.citation.startPage137pt
oaire.citation.titleJournal of the Royal Society Interfacept
rcaap.rightsrestrictedAccesspt
rcaap.typearticlept

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