Logical modelling uncovers developmental constraints for primary sex determination of chicken gonads

Sánchez, Lucas; Chaouiya, Claudine

Publication

Logical modelling uncovers developmental constraints for primary sex determination of chicken gonads

2018-05-23Journal article

dc.contributor.author	Sánchez, Lucas
dc.contributor.author	Chaouiya, Claudine
dc.date.accessioned	2018-05-29T09:28:36Z
dc.date.available	2018-05-29T09:28:36Z
dc.date.issued	2018-05-23
dc.description	This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: http://rsif.royalsocietypublishing.org/content/15/142/20180165	pt_PT
dc.description	This deposit is composed by the main article. The supplementary materials can be accessed through the following link: https://figshare.com/collections/Supplementary_material_from_Logical_modelling_uncovers_developmental_constraints_for_primary_sex_determination_of_chicken_gonads_/4094246	pt_PT
dc.description.abstract	In the chicken, sex determination relies on a ZZ (male)/ZW (female) chromosomal system, but underlying mechanisms are still not fully understood. The Z-dosage and the dominant W-chromosome hypotheses have been proposed to underlie primary sex determination. We present a modelling approach, which assembles the current knowledge and permits exploration of the regulation of this process in chickens. Relying on published experimental data, we assembled a gene network, which led to a logical model that integrates both the Z-dosage and dominant W hypotheses. This model showed that the sexual fate of chicken gonads results from the resolution of the mutual inhibition between DMRT1 and FOXL2, where the initial amount of DMRT1 product determines the development of the gonads. In this respect, at the initiation step, a W-factor would function as a secondary device, by reducing the amount of DMRT1 in ZW gonads when the sexual fate of the gonad is settled, that is when the SOX9 functional level is established. Developmental constraints that are instrumental in this resolution were identified. These constraints establish qualitative restrictions regarding the relative transcription rates of the genes DMRT1, FOXL2 and HEMGN. Our model further clarified the role of OESTROGEN in maintaining FOXL2 function during ovary development.	pt_PT
dc.description.sponsorship	L.S. received no financial support for this work. C.C. acknowledges the support of the Calouste Gulbenkian Foundation.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Sánchez L, Chaouiya C. 2018 Logical modelling uncovers developmental constraints for primary sex determination of chicken gonads. J. R. Soc. Interface 15: 20180165. http://dx.doi.org/10.1098/rsif.2018.0165	pt_PT
dc.identifier.doi	10.1098/rsif.2018.0165	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/887
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Royal Society, The	pt_PT
dc.relation.publisherversion	http://rsif.royalsocietypublishing.org/content/15/142/20180165	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	primary sex determination	pt_PT
dc.subject	chicken	pt_PT
dc.subject	gene regulatory network	pt_PT
dc.subject	logical modelling	pt_PT
dc.title	Logical modelling uncovers developmental constraints for primary sex determination of chicken gonads	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	10	pt_PT
oaire.citation.issue	142	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	Interface	pt_PT
oaire.citation.volume	15	pt_PT
rcaap.rights	restrictedAccess	pt_PT
rcaap.type	article	pt_PT