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dachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesis

2016-07-21Journal article Open access
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dc.contributor.authorBrás-Pereira, Catarina
dc.contributor.authorPotier, Delphine
dc.contributor.authorJacobs, Jelle
dc.contributor.authorAerts, Stein
dc.contributor.authorCasares, Fernando
dc.contributor.authorJanody, Florence
dc.date.accessioned2016-08-11T15:31:33Z
dc.date.available2016-08-11T15:31:33Z
dc.date.issued2016-07-21
dc.description.abstractProper organ patterning depends on a tight coordination between cell proliferation and differentiation. The patterning of Drosophila retina occurs both very fast and with high precision. This process is driven by the dynamic changes in signaling activity of the conserved Hedgehog (Hh) pathway, which coordinates cell fate determination, cell cycle and tissue morphogenesis. Here we show that during Drosophila retinogenesis, the retinal determination gene dachshund (dac) is not only a target of the Hh signaling pathway, but is also a modulator of its activity. Using developmental genetics techniques, we demonstrate that dac enhances Hh signaling by promoting the accumulation of the Gli transcription factor Cubitus interruptus (Ci) parallel to or downstream of fused. In the absence of dac, all Hh-mediated events associated to the morphogenetic furrow are delayed. One of the consequences is that, posterior to the furrow, dac- cells cannot activate a Roadkill-Cullin3 negative feedback loop that attenuates Hh signaling and which is necessary for retinal cells to continue normal differentiation. Therefore, dac is part of an essential positive feedback loop in the Hh pathway, guaranteeing the speed and the accuracy of Drosophila retinogenesis.pt_PT
dc.description.sponsorshipMINECO Spain grants: (BFU2012-34324, BFU2015- 66040); Research Foundation—Flanders FWO grants: (G.0640.13, G.0791.14, PhD fellowship); Fundação para a Ciência e Tecnologia grant: (IF/01031/2012).pt_PT
dc.identifier.citationBrás-Pereira C, Potier D, Jacobs J, Aerts S, Casares F, Janody F (2016) dachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesis. PLoS Genet 12(7): e1006204. doi:10.1371/journal.pgen.1006204pt_PT
dc.identifier.doi10.1371/journal.pgen.1006204pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/684
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.relationMolecular control of actin dynamics and change in cell shape in the morphogenetic furrow during Drosophila eye development.
dc.relation.publisherversionhttp://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006204pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHedgehog signalingpt_PT
dc.subjectCloningpt_PT
dc.subjectEyespt_PT
dc.subjectCell differentiationpt_PT
dc.subjectCell cycle and cell divisionpt_PT
dc.subjectImaginal discspt_PT
dc.subjectDrosophila melanogasterpt_PT
dc.subjectNeuronal differentiationpt_PT
dc.titledachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMolecular control of actin dynamics and change in cell shape in the morphogenetic furrow during Drosophila eye development.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-BCM%2F71674%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F46983%2F2008/PT
oaire.citation.endPage21pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePLoS Geneticspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication8f380cbd-bd87-44dd-8d3b-0c3a4eec25d0
relation.isProjectOfPublication22750648-2fc6-444c-99e5-80ed60e97f4e
relation.isProjectOfPublication.latestForDiscovery22750648-2fc6-444c-99e5-80ed60e97f4e

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