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Dynamical Scenarios for Chromosome Bi-orientation

2013-06-18Journal article Open access
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dc.contributor.authorZhang, Tongli
dc.contributor.authorOliveira, Raquel A.
dc.contributor.authorSchmierer, Bernhard
dc.contributor.authorNovák, Béla
dc.date.accessioned2016-06-27T16:41:47Z
dc.date.available2016-06-27T16:41:47Z
dc.date.issued2013-06-18
dc.description.abstractChromosome bi-orientation at the metaphase spindle is essential for precise segregation of the genetic material. The process is error-prone, and error-correction mechanisms exist to switch misaligned chromosomes to the correct, bi-oriented configuration. Here, we analyze several possible dynamical scenarios to explore how cells might achieve correct bi-orientation in an efficient and robust manner. We first illustrate that tension-mediated feedback between the sister kinetochores can give rise to a bistable switch, which allows robust distinction between a loose attachment with low tension and a strong attachment with high tension. However, this mechanism has difficulties in explaining how bi-orientation is initiated starting from unattached kinetochores. We propose four possible mechanisms to overcome this problem (exploiting molecular noise; allowing an efficient attachment of kinetochores already in the absence of tension; a trial-and-error oscillation; and a stochastic bistable switch), and assess their impact on the bi-orientation process. Based on our results and supported by experimental data, we put forward a trial-and-error oscillation and a stochastic bistable switch as two elegant mechanisms with the potential to promote bi-orientation both efficiently and robustly.pt_PT
dc.description.sponsorshipKavli Institute for Theoretical Physics grant: (NSF PHY11-25915).pt_PT
dc.identifier.citationTongli Zhang, Raquel A. Oliveira, Bernhard Schmierer, Béla Novák, Dynamical Scenarios for Chromosome Bi-orientation, Biophysical Journal, Volume 104, Issue 12, 18 June 2013, Pages 2595-2606, ISSN 0006-3495, http://dx.doi.org/10.1016/j.bpj.2013.05.005. (http://www.sciencedirect.com/science/article/pii/S0006349513005298)pt_PT
dc.identifier.doi10.1016/j.bpj.2013.05.005pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/666
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCell Presspt_PT
dc.relationEukaryotic unicellular organism biology – systems biology of the control of cell growth and proliferation
dc.relationSystems Biology of Mitosis
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0006349513005298pt_PT
dc.subjectAnimalspt_PT
dc.subjectChromosome Segregationpt_PT
dc.subjectChromosomespt_PT
dc.subjectHumanspt_PT
dc.subjectKinetochorespt_PT
dc.subjectStochastic Processespt_PT
dc.subjectChromosome Positioningpt_PT
dc.subjectModels, Geneticpt_PT
dc.titleDynamical Scenarios for Chromosome Bi-orientationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEukaryotic unicellular organism biology – systems biology of the control of cell growth and proliferation
oaire.awardTitleSystems Biology of Mitosis
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/201142/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/241548/EU
oaire.citation.endPage2606pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage2595pt_PT
oaire.citation.titleBiophysical Journalpt_PT
oaire.citation.volume104pt_PT
oaire.fundingStreamFP7
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationff7016ea-a6a3-41b1-8172-2ebe70f36278
relation.isProjectOfPublication893e9741-5024-4d4e-9a1f-a02b286c5f36
relation.isProjectOfPublication.latestForDiscoveryff7016ea-a6a3-41b1-8172-2ebe70f36278

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