Repository logo
 
Publication

Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases

dc.contributor.authorCrozet, Pierre
dc.contributor.authorMargalha, Leonor
dc.contributor.authorConfraria, Ana
dc.contributor.authorRodrigues, Américo
dc.contributor.authorMartinho, Cláudia
dc.contributor.authorAdamo, Mattia
dc.contributor.authorElias, Carlos A.
dc.contributor.authorBaena-González, Elena
dc.date.accessioned2015-10-01T14:55:57Z
dc.date.available2015-10-01T14:55:57Z
dc.date.issued2014-05-20
dc.description.abstractThe SNF1 (sucrose non-fermenting 1)-related protein kinases 1 (SnRKs1) are the plant orthologs of the budding yeast SNF1 and mammalian AMPK (AMP-activated protein kinase). These evolutionarily conserved kinases are metabolic sensors that undergo activation in response to declining energy levels. Upon activation, SNF1/AMPK/SnRK1 kinases trigger a vast transcriptional and metabolic reprograming that restores energy homeostasis and promotes tolerance to adverse conditions, partly through an induction of catabolic processes and a general repression of anabolism. These kinases typically function as a heterotrimeric complex composed of two regulatory subunits, β and γ, and an α-catalytic subunit, which requires phosphorylation of a conserved activation loop residue for activity. Additionally, SNF1/AMPK/SnRK1 kinases are controlled by multiple mechanisms that have an impact on kinase activity, stability, and/or subcellular localization. Here we will review current knowledge on the regulation of SNF1/AMPK/SnRK1 by upstream components, post-translational modifications, various metabolites, hormones, and others, in an attempt to highlight both the commonalities of these essential eukaryotic kinases and the divergences that have evolved to cope with the particularities of each one of these systems.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia fellowships (SFRH/BPD/79255/2011,SFRH/BPD/47280/2008, SFRH/BD/51627/2011, SFRH/BD/33563/2008 ); EMBO Installation Program, Marie Curie Actions FP7-People- 2010-ITN (MERIT).pt_PT
dc.identifier10.3389/fpls.2014.00190
dc.identifier.doi10.3389/fpls.2014.00190
dc.identifier.doi10.3389/fpls.2014.00190
dc.identifier.urihttp://hdl.handle.net/10400.7/333
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Research Foundationpt_PT
dc.relation.publisherversionhttp://journal.frontiersin.org/article/10.3389/fpls.2014.00190/abstractpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSnRK1pt_PT
dc.subjectSNF1pt_PT
dc.subjectAMPKpt_PT
dc.subjectstresspt_PT
dc.subjectenergy signalingpt_PT
dc.subjectArabidopsispt_PT
dc.subjectkinase regulationpt_PT
dc.titleMechanisms of regulation of SNF1/AMPK/SnRK1 protein kinasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-PLA%2F3937%2F2012/PT
oaire.citation.endPage17pt_PT
oaire.citation.issue190pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Plant Sciencept_PT
oaire.citation.volume5pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationa66ae9e4-3bd5-4638-8e2a-ffce8f6d3488
relation.isProjectOfPublication.latestForDiscoverya66ae9e4-3bd5-4638-8e2a-ffce8f6d3488

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Baena-Gonzalez_Front.Plant.Sci.(2014).pdf
Size:
1.63 MB
Format:
Adobe Portable Document Format
Description:
main article
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:

Collections