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Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses

2013-03-10Journal article Restricted access
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dc.contributor.authorHirota, Keiji
dc.contributor.authorTurner, Jan-Eric
dc.contributor.authorVilla, Matteo
dc.contributor.authorDuarte, João H
dc.contributor.authorDemengeot, Jocelyne
dc.contributor.authorSteinmetz, Oliver M
dc.contributor.authorStockinger, Brigitta
dc.date.accessioned2018-03-05T17:03:26Z
dc.date.available2018-03-05T17:03:26Z
dc.date.issued2013-03-10
dc.descriptionThis deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672955/pt_PT
dc.description.abstractIntestinal Peyer's patches are essential lymphoid organs for the generation of T cell-dependent immunoglobulin A (IgA) for gut homeostasis. Through the use of interleukin 17 (IL-17) fate-reporter mice, we found here that endogenous cells of the TH17 subset of helper T cells in lymphoid organs of naive mice 'preferentially' homed to the intestines and were maintained independently of IL-23. In Peyer's patches, such TH17 cells acquired a follicular helper T cell (TFH cell) phenotype and induced the development of IgA-producing germinal center B cells. Mice deficient in TH17 cells failed to generate antigen-specific IgA responses, which provides evidence that TH17 cells are the crucial subset required for the production of high-affinity T cell-dependent IgA.pt_PT
dc.description.sponsorshipEuropean Mouse Mutant Archive; European Union Framework Programme 7 Capacities Specific Program (for axenization), Medical Research Council UK grant: (U117512792); Deutsche Forschungsgemeinschaft grant: (TU 316/1-1); Boehringer Ingelheim Fonds.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNature Immunology volume 14, pages 372–379 (2013)pt_PT
dc.identifier.doi10.1038/ni.2552pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/849
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Publishing Grouppt_PT
dc.relationU117512792pt_PT
dc.relationTU 316/1-1pt_PT
dc.relation.publisherversionhttps://www.nature.com/articles/ni.2552pt_PT
dc.subjectAntibodiespt_PT
dc.subjectImmunologypt_PT
dc.subjectMucosal immunologypt_PT
dc.subjectT-helper 17 cellspt_PT
dc.titlePlasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responsespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage379pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage372pt_PT
oaire.citation.titleNature Immunologypt_PT
oaire.citation.volume14pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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