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Muller's ratchet in random graphs and scale free networks

2006-10Journal article Open access
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dc.contributor.authorCampos, P.R.A.
dc.contributor.authorCombadão, J.
dc.contributor.authorDionísio, F.
dc.contributor.authorGordo, I.
dc.date.accessioned2010-03-25T12:08:35Z
dc.date.available2010-03-25T12:08:35Z
dc.date.issued2006-10
dc.description.abstractMuller's ratchet is an evolutionary process that has been implicated in the extinction of asexual species, the evolution of mitochondria, the degeneration of the Y chromosome, the evolution of sex and recombination and the evolution of microbes. Here we study the speed of Muller's ratchet in a population subdivided into many small subpopulations connected by migration, and distributed on a network. We compare the speed of the ratchet in two distinct types of topologies: scale free networks and random graphs. The difference between the topologies is noticeable when the average connectivity of the network and the migration rate is large. In this situation we observe that the ratchet clicks faster in scale free networks than in random graphs. So contrary to intuition, scale free networks are more prone to loss of genetic information than random graphs. On the other hand, we show that scale free networks are more robust to the random extinction than random graphs. Since these complex networks have been shown to describe well real-life systems, our results open a framework for studying the evolution of microbes and disease epidemics.pt
dc.identifier.citationCampos PRA, Combadão J , Dionisio F. and I. Gordo (2006) Muller's ratchet in random graphs and scale free networks Phys. Rev. E 74, 042901pt
dc.identifier.doi10.1103/PhysRevE.74.042901pt_PT
dc.identifier.issn1539-3755
dc.identifier.urihttp://hdl.handle.net/10400.7/84
dc.language.isoengpt
dc.publisherAmerican Physical Societypt
dc.subjectAlgorithmspt
dc.subjectEvolutionpt
dc.subjectExtinction, Biologicalpt
dc.subjectGenetics, Populationpt
dc.subjectModels, Biologicalpt
dc.subjectPopulation Growthpt
dc.subjectReproduction, Asexual/geneticspt
dc.subjectSpeedpt
dc.subjectAccumulationpt
dc.subjectSpreadpt
dc.titleMuller's ratchet in random graphs and scale free networkspt
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage042901-4pt
oaire.citation.startPage042901-1pt
oaire.citation.titlePhysical Review Ept
rcaap.rightsopenAccesspt
rcaap.typearticlept

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