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Expression Profile of microRNAs Regulating Proliferation and Differentiation in Mouse Adult Cardiac Stem Cells

2013-05-17Journal article Open access
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dc.contributor.authorBrás-Rosário, Luis
dc.contributor.authorMatsuda, Alex
dc.contributor.authorPinheiro, Ana Isabel
dc.contributor.authorGardner, Rui
dc.contributor.authorLopes, Telma
dc.contributor.authorAmaral, Andreia
dc.contributor.authorGama-Carvalho, Margarida
dc.date.accessioned2015-11-19T12:56:05Z
dc.date.available2015-11-19T12:56:05Z
dc.date.issued2013-05-17
dc.description.abstractThe identification of cardiac cells with stem cell properties changed the paradigm of the heart as a post mitotic organ. These cells proliferate and differentiate into cardiomyocytes, endothelial and vascular smooth muscle cells, providing for cardiac cell homeostasis and regeneration. microRNAs are master switches controlling proliferation and differentiation, in particular regulating stem cell biology and cardiac development. Modulation of microRNAs -regulated gene expression networks holds the potential to control cell fate and proliferation, with predictable biotechnologic and therapeutic applications. To obtain insights into the regulatory networks active in cardiac stem cells, we characterized the expression profile of 95 microRNAs with reported functions in stem cell and tissue differentiation in mouse cardiac stem cells, and compared it to that of mouse embryonic heart and mesenchymal stem cells. The most highly expressed microRNAs identified in cardiac stem cells are known to target key genes involved in the control of cell proliferation and adhesion, vascular function and cardiomyocyte differentiation. We report a subset of differentially expressed microRNAs that are proposed to act as regulators of differentiation and proliferation of adult cardiac stem cells, providing novel insights into active gene expression networks regulating their biological properties.pt_PT
dc.identifier.citationBra ́ s-Rosa ́ rio L, Matsuda A, Pinheiro AI, Gardner R, Lopes T, et al. (2013) Expression Profile of microRNAs Regulating Proliferation and Differentiation in Mouse Adult Cardiac Stem Cells. PLoS ONE 8(5): e63041. doi:10.1371/journal.pone.0063041pt_PT
dc.identifier.doi10.1371/journal.pone.0063041pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/509
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLOSpt_PT
dc.relationThese authors have no support or funding to report.pt_PT
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063041pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAdult Stem Cellspt_PT
dc.subjectHeartpt_PT
dc.subjectCell differentiationpt_PT
dc.subjectMuscle differentiationpt_PT
dc.subjectStem cellspt_PT
dc.subjectFluorescence-activated cell sortingpt_PT
dc.subjectEmbryonic stem cellspt_PT
dc.subjectGene expressionpt_PT
dc.titleExpression Profile of microRNAs Regulating Proliferation and Differentiation in Mouse Adult Cardiac Stem Cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage10pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePLOS Onept_PT
oaire.citation.volume8pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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