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Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice

2019-03-15Journal article Open access
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dc.contributor.authorMurillo-León, Mateo
dc.contributor.authorMüller, Urs B
dc.contributor.authorZimmermann, Ines
dc.contributor.authorSingh, Shishir
dc.contributor.authorWiddershooven, Pia
dc.contributor.authorCampos, Cláudia
dc.contributor.authorAlvarez, Catalina
dc.contributor.authorKönen-Waisman, Stephanie
dc.contributor.authorLukes, Nahleen
dc.contributor.authorRuzsics, Zsolt
dc.contributor.authorHoward, Jonathan C
dc.contributor.authorSchwemmle, Martin
dc.contributor.authorSteinfeldt, Tobias
dc.date.accessioned2020-03-11T10:44:22Z
dc.date.available2020-03-11T10:44:22Z
dc.date.issued2019-03-15
dc.description.abstractSome strains of the protozoan parasite Toxoplasma gondii (such as RH) are virulent in laboratory mice because they are not restricted by the Immunity-Related GTPase (IRG) resistance system in these mouse strains. In some wild-derived Eurasian mice (such as CIM) on the other hand, polymorphic IRG proteins inhibit the replication of such virulent T. gondii strains. Here we show that this resistance is due to direct binding of the IRG protein Irgb2-b1CIM to the T. gondii virulence effector ROP5 isoform B. The Irgb2-b1 interface of this interaction is highly polymorphic and under positive selection. South American T. gondii strains are virulent even in wild-derived Eurasian mice. We were able to demonstrate that this difference in virulence is due to polymorphic ROP5 isoforms that are not targeted by Irgb2-b1CIM, indicating co-adaptation of host cell resistance GTPases and T. gondii virulence effectors.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMurillo-León M, Müller UB, Zimmermann I, et al. Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice [published correction appears in Nat Commun. 2019 Apr 4;10(1):1645]. Nat Commun. 2019;10(1):1233. Published 2019 Mar 15pt_PT
dc.identifier.doi10.1038/s41467-019-09200-2pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/930
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAnimalspt_PT
dc.subjectDisease Resistancept_PT
dc.subjectFemalept_PT
dc.subjectFibroblastspt_PT
dc.subjectGTP Phosphohydrolasespt_PT
dc.subjectHEK293 Cellspt_PT
dc.subjectHost-Parasite Interactionspt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMicept_PT
dc.subjectMice, Inbred C57BLpt_PT
dc.subjectProtein Isoformspt_PT
dc.subjectProtozoan Proteinspt_PT
dc.subjectSelection, Geneticpt_PT
dc.subjectToxoplasmapt_PT
dc.subjectToxoplasmosis, Animalpt_PT
dc.subjectVirulencept_PT
dc.titleMolecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived micept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage1233pt_PT
oaire.citation.titleNature communicationspt_PT
oaire.citation.volume10pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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