Publication
Reorganisation ofHoxdregulatory landscapes during the evolution of a snake-like body plan
| dc.contributor.author | Guerreiro, Isabel | |
| dc.contributor.author | Gitto, Sandra | |
| dc.contributor.author | Novoa, Ana | |
| dc.contributor.author | Codourey, Julien | |
| dc.contributor.author | Nguyen Huynh, Thi Hanh | |
| dc.contributor.author | Gonzalez, Federico | |
| dc.contributor.author | Milinkovitch, Michel C | |
| dc.contributor.author | Mallo, Moises | |
| dc.contributor.author | Duboule, Denis | |
| dc.date.accessioned | 2016-08-11T16:23:40Z | |
| dc.date.available | 2016-08-11T16:23:40Z | |
| dc.date.issued | 2016-08-01 | |
| dc.description.abstract | Within land vertebrate species, snakes display extreme variations in their body plan, characterized by the absence of limbs and an elongated morphology. Such a particular interpretation of the basic vertebrate body architecture has often been associated with changes in the function or regulation of Hox genes. Here, we use an interspecies comparative approach to investigate different regulatory aspects at the snake HoxD locus. We report that, unlike in other vertebrates, snake mesoderm-specific enhancers are mostly located within the HoxD cluster itself rather than outside. In addition, despite both the absence of limbs and an altered Hoxd gene regulation in external genitalia, the limb-associated bimodal HoxD chromatin structure is maintained at the snake locus. Finally, we show that snake and mouse orthologous enhancer sequences can display distinct expression specificities. These results show that vertebrate morphological evolution likely involved extensive reorganisation at Hox loci, yet within a generally conserved regulatory framework. | pt_PT |
| dc.description.sponsorship | Fundação para a Ciência e Tecnologia grant: (PTDB/BEX-BID/0899/2014); Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung grant: (310030B_138662); Claraz Foundation; Université de Genève; Instituto Federal de Educação Ciência e Tecnologia do Espírito Santo. | pt_PT |
| dc.identifier.citation | eLife 2016;5:e16087 | pt_PT |
| dc.identifier.doi | 10.7554/eLife.16087 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.7/685 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | eLife Sciences Publications | pt_PT |
| dc.relation | A System Approach to Hox Genes Regulation in Vertebrates | |
| dc.relation.publisherversion | https://elifesciences.org/content/5/e16087 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | developmental biology | pt_PT |
| dc.subject | evolutionary biology | pt_PT |
| dc.subject | genomics | pt_PT |
| dc.subject | mouse | pt_PT |
| dc.subject | reptiles | pt_PT |
| dc.subject | snakes | pt_PT |
| dc.subject | squamata | pt_PT |
| dc.subject | stem cells | pt_PT |
| dc.title | Reorganisation ofHoxdregulatory landscapes during the evolution of a snake-like body plan | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | A System Approach to Hox Genes Regulation in Vertebrates | |
| oaire.awardURI | info:eu-repo/grantAgreement/EC/FP7/232790/EU | |
| oaire.citation.endPage | 23 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.title | eLife | pt_PT |
| oaire.citation.volume | 5 | pt_PT |
| oaire.fundingStream | FP7 | |
| project.funder.identifier | http://doi.org/10.13039/501100008530 | |
| project.funder.name | European Commission | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | 9cc5b23a-deb4-4d01-9f52-2ba6be42b8d5 | |
| relation.isProjectOfPublication.latestForDiscovery | 9cc5b23a-deb4-4d01-9f52-2ba6be42b8d5 |