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Control of Uterine Microenvironment by Foxp3+ Cells Facilitates Embryo Implantation

2013-06-20Journal article Open access
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dc.contributor.authorZenclussen, Ana Claudia
dc.contributor.authorHämmerling, Günter J.
dc.contributor.authorTadokoro, Carlos Eduardo
dc.contributor.authorReichardt, Peter
dc.contributor.authorThuere, Catharina
dc.contributor.authorLinzke, Nadja
dc.contributor.authorKühnle, Marie-Cristine
dc.contributor.authorSchumacher, Anne
dc.contributor.authorTeles, Ana
dc.date.accessioned2015-11-25T17:03:11Z
dc.date.available2015-11-25T17:03:11Z
dc.date.issued2013-06-20
dc.description.abstractImplantation of the fertilized egg into the maternal uterus depends on the fine balance between inflammatory and anti-inflammatory processes. Whilst regulatory T cells (Tregs) are reportedly involved in protection of allogeneic fetuses against rejection by the maternal immune system, their role for pregnancy to establish, e.g., blastocyst implantation, is not clear. By using 2-photon imaging we show that Foxp3(+) cells accumulated in the mouse uterus during the receptive phase of the estrus cycle. Seminal fluid further fostered Treg expansion. Depletion of Tregs in two Foxp3.DTR-based models prior to pairing drastically impaired implantation and resulted in infiltration of activated T effector cells as well as in uterine inflammation and fibrosis in both allogeneic and syngeneic mating combinations. Genetic deletion of the homing receptor CCR7 interfered with accumulation of Tregs in the uterus and implantation indicating that homing of Tregs to the uterus was mediated by CCR7. Our results demonstrate that Tregs play a critical role in embryo implantation by preventing the development of a hostile uterine microenvironment.pt_PT
dc.description.sponsorshipDFG grants: (ZE526/4-2, SFB854TP7), Wilhelm Sander Stiftung Germany grant: (2009.022.1), Helmholtz Alliance for Immunotherapy, FCT, Medical Faculty Otto-von-Guericke University PhD grant.pt_PT
dc.identifier.citationTeles A, Schumacher A, Kühnle M-C, Linzke N, Thuere C, Reichardt P, Tadokoro CE, Hämmerling GJ and Zenclussen AC (2013) Control of uterine microenvironment by Foxp3+ cells facilitates embryo implantation. Front. Immunol. 4:158. doi: 10.3389/fimmu.2013.00158 Günter J. Hämmerling and Ana Claudia Zenclussen are co-senior authors.pt_PT
dc.identifier.doi10.3389/fimmu.2013.00158pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/526
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Research Foundationpt_PT
dc.relation.publisherversionhttp://journal.frontiersin.org/article/10.3389/fimmu.2013.00158/abstractpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectregulatory T cellspt_PT
dc.subjectimplantationpt_PT
dc.subjectpregnancypt_PT
dc.subjectfibrosispt_PT
dc.subjectinflammationpt_PT
dc.titleControl of Uterine Microenvironment by Foxp3+ Cells Facilitates Embryo Implantationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage12pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Immunologypt_PT
oaire.citation.volume4pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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