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Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases

2017-06-15Journal article Open access
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dc.contributor.authorCascão, Rita
dc.contributor.authorFonseca, João E.
dc.contributor.authorMoita, Luis F.
dc.date.accessioned2017-07-12T11:27:21Z
dc.date.available2017-07-12T11:27:21Z
dc.date.issued2017-06-15
dc.descriptionThis deposit is composed by the main article, and it hasn't any supplementary materials associated.pt_PT
dc.description.abstractThe identification of new bioactive compounds derived from medicinal plants with significant therapeutic properties has attracted considerable interest in recent years. Such is the case of the Tripterygium wilfordii (TW), an herb used in Chinese medicine. Clinical trials performed so far using its root extracts have shown impressive therapeutic properties but also revealed substantial gastrointestinal side effects. The most promising bioactive compound obtained from TW is celastrol. During the last decade, an increasing number of studies were published highlighting the medicinal usefulness of celastrol in diverse clinical areas. Here we systematically review the mechanism of action and the therapeutic properties of celastrol in inflammatory diseases, namely, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, osteoarthritis and allergy, as well as in cancer, neurodegenerative disorders and other diseases, such as diabetes, obesity, atherosclerosis, and hearing loss. We will also focus in the toxicological profile and limitations of celastrol formulation, namely, solubility, bioavailability, and dosage issues that still limit its further clinical application and usefulness.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia grants: (SFRH/BPD/92860/2013, PTDC/BIM-MEC/4665/2014); European Research Council grants: (ERC-2014-CoG 647888-iPROTECTION).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCascão R, Fonseca JE and Moita LF (2017) Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases. Front. Med. 4:69. doi: 10.3389/fmed.2017.00069pt_PT
dc.identifier.doi10.3389/fmed.2017.00069pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/773
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relationERC-2014-CoG 647888-iPROTECTIONpt_PT
dc.relationEvaluation of celastrol as a candidate for the treatment of rheumatoid arthritis
dc.relation.publisherversionhttp://journal.frontiersin.org/article/10.3389/fmed.2017.00069/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectcelastrolpt_PT
dc.subjectinflammationpt_PT
dc.subjectcancerpt_PT
dc.subjectneurodegenerative diseasespt_PT
dc.subjecttoxicitypt_PT
dc.subjecttreatmentpt_PT
dc.subjectclinical trialspt_PT
dc.titleCelastrol: A Spectrum of Treatment Opportunities in Chronic Diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEvaluation of celastrol as a candidate for the treatment of rheumatoid arthritis
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F92860%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIM-MEC%2F4665%2F2014/PT
oaire.citation.endPage18pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Medicinept_PT
oaire.citation.volume4pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationd0fe7b50-1859-4c19-aede-47dc1e77e233
relation.isProjectOfPublicationc077d71d-30a3-4d76-bcf0-59eaaa98408f
relation.isProjectOfPublication.latestForDiscoveryd0fe7b50-1859-4c19-aede-47dc1e77e233

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