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Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production

2012Journal article Open access
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dc.contributor.authorFaustino, Lucas
dc.contributor.authorMucida, Daniel
dc.contributor.authorKeller, Alexandre Castro
dc.contributor.authorDemengeot, Jocelyne
dc.contributor.authorBortoluci, Karina
dc.contributor.authorSardinha, Luiz Roberto
dc.contributor.authorCarla Takenaka, Maisa
dc.contributor.authorBasso, Alexandre Salgado
dc.contributor.authorFaria, Ana Maria Caetano
dc.contributor.authorRusso, Momtchilo
dc.date.accessioned2016-06-09T15:59:52Z
dc.date.available2016-06-09T15:59:52Z
dc.date.issued2012
dc.descriptionThis deposit is composed by a publication in which the IGC' authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and could only be accessed by two ways: either by requesting a legal copy to the author (the email contact present in this deposit) or by visiting the following link: http://bdpi.usp.br/single.php?_id=002294086pt_PT
dc.description.abstractFoxp3(+)CD25(+)CD4(+) regulatory T cells are vital for peripheral tolerance and control of tissue inflammation. In this study, we characterized the phenotype and monitored the migration and activity of regulatory T cells present in the airways of allergic or tolerant mice after allergen challenge. To induce lung allergic inflammation, mice were sensitized twice with ovalbumin/aluminum hydroxide gel and challenged twice with intranasal ovalbumin. Tolerance was induced by oral administration of ovalbumin for 5 consecutive days prior to OVA sensitization and challenge. We detected regulatory T cells (Foxp3(+)CD25(+)CD4(+) T cells) in the airways of allergic and tolerant mice; however, the number of regulatory T cells was more than 40-fold higher in allergic mice than in tolerant mice. Lung regulatory T cells expressed an effector/memory phenotype (CCR4(high)CD62L(low)CD44(high)CD54(high)CD69(+)) that distinguished them from naive regulatory T cells (CCR4(int)CD62L(high)CD44(int)CD54(int)CD69(-)). These regulatory T cells efficiently suppressed pulmonary T-cell proliferation but not Th2 cytokine production.pt_PT
dc.description.sponsorshipFundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).pt_PT
dc.identifier.citationLucas Faustino, Daniel Mucida, Alexandre Castro Keller, et al., “Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production,” Clinical and Developmental Immunology, vol. 2012, Article ID 721817, 13 pages, 2012. doi:10.1155/2012/721817pt_PT
dc.identifier.doi10.1155/2012/721817pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/637
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawi Publishing Corporationpt_PT
dc.relation.publisherversionhttp://www.hindawi.com/journals/jir/2012/721817/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectAntigens, CD4pt_PT
dc.subjectAsthmapt_PT
dc.subjectCytokinespt_PT
dc.subjectFemalept_PT
dc.subjectInterleukin-2 Receptor alpha Subunitpt_PT
dc.subjectLungpt_PT
dc.subjectMicept_PT
dc.subjectMice, Inbred BALB Cpt_PT
dc.subjectPneumoniapt_PT
dc.subjectT-Lymphocytes, Regulatorypt_PT
dc.subjectTh2 Cellspt_PT
dc.subjectCell Proliferationpt_PT
dc.titleRegulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Productionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage13pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleClinical and Developmental Immunologypt_PT
oaire.citation.volume2012pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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