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Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy

2013-08-23Journal article Open access
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dc.contributor.authorTeresa Avelar, Ana
dc.contributor.authorPerfeito, Lília
dc.contributor.authorGordo, Isabel
dc.contributor.authorGodinho Ferreira, Miguel
dc.date.accessioned2015-10-22T10:24:35Z
dc.date.available2015-10-22T10:24:35Z
dc.date.issued2013-08-23
dc.description.abstractChromosomal rearrangements are mutations contributing to both within and between species variation; however their contribution to fitness is yet to be measured. Here we show that chromosomal rearrangements are pervasive in natural isolates of Schizosaccharomyces pombe and contribute to reproductive isolation. To determine the fitness effects of chromosome structure, we constructed two inversions and eight translocations without changing the coding sequence. We show that chromosomal rearrangements contribute to both reproductive success in meiosis and growth rate in mitosis with a strong genotype by environment interaction. These changes are accompanied by alterations in gene expression. Strikingly, we find several examples leading to antagonistic pleiotropy. Even though chromosomal rearrangements may have a deleterious effect during sexual reproduction, some compensate with a strong growth advantage in mitosis. Our results constitute the first quantification of fitness effects caused by de novo mutations that result in chromosomal rearrangement variation and suggest a mechanism for their maintenance in natural populations.pt_PT
dc.description.sponsorshipFCT PhD and Postdoctoral fellowships.pt_PT
dc.identifier10.1038/ncomms3235
dc.identifier.citationAvelar, A. T. et al. Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy. Nat. Commun. 4:2235 doi: 10.1038/ncomms3235 (2013).pt_PT
dc.identifier.doi10.1038/ncomms3235
dc.identifier.doi10.1038/ncomms3235
dc.identifier.urihttp://hdl.handle.net/10400.7/426
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Publishing Grouppt_PT
dc.relation.publisherversionhttp://www.nature.com/ncomms/2013/130823/ncomms3235/full/ncomms3235.htmlpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiological sciencespt_PT
dc.subjectEvolutionpt_PT
dc.subjectGeneticspt_PT
dc.titleGenome architecture is a selectable trait that can be maintained by antagonistic pleiotropypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-EVF%2F114460%2F2009/PT
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleNature Communicationspt_PT
oaire.citation.volume4pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication0e359e59-993e-4124-ae35-4f2e74d0f29a
relation.isProjectOfPublication.latestForDiscovery0e359e59-993e-4124-ae35-4f2e74d0f29a

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