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Route of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or Foxp3-Independent Dominant Immune Tolerance

2018-01-01Journal article Restricted access
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dc.contributor.authorAgua-Doce, Ana
dc.contributor.authorCaridade, Marta
dc.contributor.authorOliveira, Vanessa G
dc.contributor.authorBergman, Lisa
dc.contributor.authorLafaille, Maria C
dc.contributor.authorLafaille, Juan J
dc.contributor.authorDemengeot, Jocelyne
dc.contributor.authorGraca, Luis
dc.date.accessioned2018-03-01T17:49:56Z
dc.date.available2018-03-01T17:49:56Z
dc.date.issued2018-01-01
dc.descriptionThis deposit is composed by a publication in which the IGC' authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and could only be accessed by two ways: either by requesting a legal copy to the author (the email contact present in this deposit) or by visiting the following link: http://www.jimmunol.org/content/200/1/101.long#ack-1pt_PT
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.description.abstractIt has been shown that dominant tolerance, namely in transplantation, requires Foxp3+regulatory T cells. Although most tolerance-inducing regimens rely on regulatory T cells, we found that induction of tolerance to proteins in aluminum hydroxide can be achieved in Foxp3-deficient mice using nondepleting anti-CD4 Abs. This type of tolerance is Ag specific, and tolerant mice retain immune competence to respond to unrelated Ags. We demonstrated with chicken OVA-specific TCR-transgenic mice that the same tolerizing protocol (CD4 blockade) and the same target Ag (OVA) achieves Foxp3-dependent transplantation tolerance to OVA-expressing skin grafts, but Foxp3-independent tolerance when the Ag is provided as OVA-aluminum hydroxide. In the latter case, we found that tolerance induction triggered recessive mechanisms leading to elimination of effector cells and, simultaneously, a dominant mechanism associated with the emergence of an anergic and regulatory CTLA-4+IL-2lowFoxp3-T cell population, where the tolerance state is IL-10 dependent. Such Foxp3-independent mechanisms can improve the efficacy of tolerance-inducing protocols.pt_PT
dc.description.sponsorshipFundacao para a Ciencia e Tecnologia grant: (HMSP-ICT/0034/2013); FEDER through POR Lisboa 2020–Programa Operacional Regional de Lisboa grant: (LISBOA-01-0145-FEDER-007391).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRoute of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or Foxp3-Independent Dominant Immune Tolerance Ana Agua-Doce, Marta Caridade, Vanessa G. Oliveira, Lisa Bergman, Maria C. Lafaille, Juan J. Lafaille, Jocelyne Demengeot, Luis Graca The Journal of Immunology January 1, 2018, 200 (1) 101-109; DOI: 10.4049/jimmunol.1601886pt_PT
dc.identifier.doi10.4049/jimmunol.1601886pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/843
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Association of Immunologistspt_PT
dc.relationGrant LISBOA-01-0145-FEDER-007391pt_PT
dc.relation.publisherversionhttp://www.jimmunol.org/content/200/1/101pt_PT
dc.subjectAluminum Hydroxidept_PT
dc.subjectAnimalspt_PT
dc.subjectAntibodiespt_PT
dc.subjectAntigen Presentationpt_PT
dc.subjectCD4 Antigenspt_PT
dc.subjectCell Differentiationpt_PT
dc.subjectCells, Culturedpt_PT
dc.subjectClonal Selection, Antigen-Mediatedpt_PT
dc.subjectForkhead Transcription Factorspt_PT
dc.subjectInterleukin-10pt_PT
dc.subjectInterleukin-2pt_PT
dc.subjectLymphocyte Activationpt_PT
dc.subjectMicept_PT
dc.subjectMice, Knockoutpt_PT
dc.subjectMice, Transgenicpt_PT
dc.subjectOvalbuminpt_PT
dc.subjectT-Lymphocyte Subsetspt_PT
dc.subjectT-Lymphocytes, Regulatorypt_PT
dc.subjectImmune Tolerancept_PT
dc.subjectSkin Transplantationpt_PT
dc.titleRoute of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or Foxp3-Independent Dominant Immune Tolerancept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/HMSP-ICT%2F0034%2F2013/PT
oaire.citation.endPage109pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage101pt_PT
oaire.citation.titleJournal of Immunologypt_PT
oaire.citation.volume200pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationbf65561d-2f78-4aa7-81ae-4c339603c25c
relation.isProjectOfPublication.latestForDiscoverybf65561d-2f78-4aa7-81ae-4c339603c25c

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