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Logical Modeling and Dynamical Analysis of Cellular Networks

2016-05-31Journal article Open access
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dc.contributor.authorAbou-Jaoudé, Wassim
dc.contributor.authorTraynard, Pauline
dc.contributor.authorMonteiro, Pedro T.
dc.contributor.authorSaez-Rodriguez, Julio
dc.contributor.authorHelikar, Tomáš
dc.contributor.authorThieffry, Denis
dc.contributor.authorChaouiya, Claudine
dc.date.accessioned2016-06-20T12:40:07Z
dc.date.available2016-06-20T12:40:07Z
dc.date.issued2016-05-31
dc.description.abstractThe logical (or logic) formalism is increasingly used to model regulatory and signaling networks. Complementing these applications, several groups contributed various methods and tools to support the definition and analysis of logical models. After an introduction to the logical modeling framework and to several of its variants, we review here a number of recent methodological advances to ease the analysis of large and intricate networks. In particular, we survey approaches to determine model attractors and their reachability properties, to assess the dynamical impact of variations of external signals, and to consistently reduce large models. To illustrate these developments, we further consider several published logical models for two important biological processes, namely the differentiation of T helper cells and the control of mammalian cell cycle.pt_PT
dc.description.sponsorshipLabEx MemoLife; Ecole Normale Supérieure; French Plan Cancer (2014–2017) project: (Modeling cell communication networks in breast cancer - CoMET); FCT grants: (UID/CEC/50021/2013, IF/01333/2013); Fundação Calouste Gulbenkian.pt_PT
dc.identifier.citationAbou-JaoudéW,TraynardP, Monteiro PT,Saez-RodriguezJ, HelikarT,ThieffryDandChaouiyaC (2016) LogicalModelingand DynamicalAnalysisofCellular Networks.Front.Genet.7:94. doi: 10.3389/fgene.2016.00094pt_PT
dc.identifier.doi10.3389/fgene.2016.00094pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/656
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers in Geneticspt_PT
dc.relation.publisherversionhttp://journal.frontiersin.org/article/10.3389/fgene.2016.00094/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectregulatory and signaling networkspt_PT
dc.subjectlogical modelingpt_PT
dc.subjectdiscrete dynamicspt_PT
dc.subjectattractorspt_PT
dc.subjectreachability analysispt_PT
dc.subjectsimulationpt_PT
dc.subjectT cells activation and differentiationpt_PT
dc.subjectcell cycle controlpt_PT
dc.titleLogical Modeling and Dynamical Analysis of Cellular Networkspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage20pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Geneticspt_PT
oaire.citation.volume7pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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