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Myocardial aging as a T-cell–mediated phenomenon

2017-03-21Journal article Restricted access
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dc.contributor.authorRamos, Gustavo Campos
dc.contributor.authorvan den Berg, Anne
dc.contributor.authorNunes-Silva, Vânia
dc.contributor.authorWeirather, Johannes
dc.contributor.authorPeters, Laura
dc.contributor.authorBurkard, Matthias
dc.contributor.authorFriedrich, Mike
dc.contributor.authorPinnecker, Jürgen
dc.contributor.authorAbeßer, Marco
dc.contributor.authorHeinze, Katrin G.
dc.contributor.authorSchuh, Kai
dc.contributor.authorBeyersdorf, Niklas
dc.contributor.authorKerkau, Thomas
dc.contributor.authorDemengeot, Jocelyne
dc.contributor.authorFrantz, Stefan
dc.contributor.authorHofmann, Ulrich
dc.date.accessioned2018-03-02T15:20:29Z
dc.date.available2018-03-02T15:20:29Z
dc.date.issued2017-03-21
dc.descriptionThis deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373357/pt_PT
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.description.abstractIn recent years, the myocardium has been rediscovered under the lenses of immunology, and lymphocytes have been implicated in the pathogenesis of cardiomyopathies with different etiologies. Aging is an important risk factor for heart diseases, and it also has impact on the immune system. Thus, we sought to determine whether immunological activity would influence myocardial structure and function in elderly mice. Morphological, functional, and molecular analyses revealed that the age-related myocardial impairment occurs in parallel with shifts in the composition of tissue-resident leukocytes and with an accumulation of activated CD4+Foxp3-(forkhead box P3) IFN-γ+T cells in the heart-draining lymph nodes. A comprehensive characterization of different aged immune-deficient mouse strains revealed that T cells significantly contribute to age-related myocardial inflammation and functional decline. Upon adoptive cell transfer, the T cells isolated from the mediastinal lymph node (med-LN) of aged animals exhibited increased cardiotropism, compared with cells purified from young donors or from other irrelevant sites. Nevertheless, these cells caused rather mild effects on cardiac functionality, indicating that myocardial aging might stem from a combination of intrinsic and extrinsic (immunological) factors. Taken together, the data herein presented indicate that heart-directed immune responses may spontaneously arise in the elderly, even in the absence of a clear tissue damage or concomitant infection. These observations might shed new light on the emerging role of T cells in myocardial diseases, which primarily affect the elderly population.pt_PT
dc.description.sponsorshipBundesministerium für Bildung und Forschung grants: (BMBF01, EO1004); German Research Foundation grant: (DFG SFB688, TP A10, and B07); Brazilian National Council for Scientific and Technological Development.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMyocardial aging as a T-cell–mediated phenomenon - Gustavo Campos Ramos, Anne van den Berg, Vânia Nunes-Silva, Johannes Weirather, Laura Peters, Matthias Burkard, Mike Friedrich, Jürgen Pinnecker, Marco Abeßer, Katrin G. Heinze, Kai Schuh, Niklas Beyersdorf, Thomas Kerkau, Jocelyne Demengeot, Stefan Frantz, Ulrich Hofmann Proceedings of the National Academy of Sciences Mar 2017, 114 (12) E2420-E2429; DOI: 10.1073/pnas.1621047114pt_PT
dc.identifier.doi10.1073/pnas.1621047114pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/844
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNational Academy of Sciencespt_PT
dc.relationBMBF01pt_PT
dc.relationEO1004pt_PT
dc.relationDFG SFB688pt_PT
dc.relationTP A10pt_PT
dc.relationB07pt_PT
dc.relation.publisherversionhttp://www.pnas.org/content/114/12/E2420pt_PT
dc.subjectmyocardialpt_PT
dc.subjectagingpt_PT
dc.subjectT cellspt_PT
dc.subjectinflammationpt_PT
dc.subjectinflammagingpt_PT
dc.titleMyocardial aging as a T-cell–mediated phenomenonpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPageE2429pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPageE2420pt_PT
oaire.citation.titleProceedings of the National Academy of Sciencespt_PT
oaire.citation.volume114pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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