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The multifaceted Foxp3fgfp allele enhances spontaneous and therapeutic immune surveillance of cancer in mice

2019-11-15Journal article Open access
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dc.contributor.authorAlmeida-Santos, Jose
dc.contributor.authorBergman, Marie-Louise
dc.contributor.authorJocelyne, Demengeot
dc.contributor.authorCorreia, Vasco
dc.contributor.authorCaramalho, Iris
dc.contributor.authorCabral, Ines
dc.date.accessioned2020-03-09T16:55:51Z
dc.date.available2020-11-01T01:30:08Z
dc.date.issued2019-11-15
dc.description.abstractIt is well established that therapeutic impairment of Foxp3+ Treg in mice and humans favors immune rejection of solid tumors. Less explored is the impact Foxp3 allelic variants may have on tumor incidence, progression and therapy. In this work, we tested and demonstrate that the Foxp3fgfp reporter allele, found previously to either enhance or reduce Treg function in specific autoimmunity settings, confers increased anti-tumor immunity. Our conclusions stem out of the analysis of three tumor models of different tissue origin, in two murine genetic backgrounds. When compared to wild type animals, mice carrying the Foxp3fgfp allele spontaneously delay, reduce or prevent primary tumor growth, decrease metastasis growth, and potentiate the response to anti-CTLA4 monotherapy. These findings suggest allelic variances at the Foxp3 locus may serve as predictive indicators for personalized therapy and prognostics, and point at possible new therapeutic targets.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/eji.201948251pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/926
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWILEY‐VCH Verlag GmbH & Co. KGaA, Weinheimpt_PT
dc.relationSFRH/BD/52435/2013pt_PT
dc.relationCONGENTO LISBOA-01-0145-FEDER-022170 (FCT, Lisboa2020, Por2020, ERDF)pt_PT
dc.relationMolecular basis of the contribution of a common AIRE allelic variant to the targeting of organ-specific autoimmunity and quality of anti-tumor responses
dc.subjectResearch Subject Categories::MEDICINEpt_PT
dc.subjectResearch Subject Categories::NATURAL SCIENCESpt_PT
dc.subjectTregpt_PT
dc.subjectFoxp3:GFP Allelic hypomorph variantpt_PT
dc.subjectTumor Immunologypt_PT
dc.titleThe multifaceted Foxp3fgfp allele enhances spontaneous and therapeutic immune surveillance of cancer in micept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMolecular basis of the contribution of a common AIRE allelic variant to the targeting of organ-specific autoimmunity and quality of anti-tumor responses
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04555%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F111454%2F2015/PT
oaire.citation.endPage444pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage439pt_PT
oaire.citation.titleEuropean Journal of Immunologypt_PT
oaire.citation.volume50pt_PT
oaire.fundingStream5876
oaire.fundingStreamOE
person.familyNameAlmeida-Santos
person.familyNameBergman
person.familyNameDemengeot
person.familyNameVieira Correia
person.familyNameCaramalho
person.givenNameJose
person.givenNameMarie-Louise
person.givenNameJocelyne
person.givenNameVasco
person.givenNameIris
person.identifier21837
person.identifier.ciencia-idD71C-9ED2-3824
person.identifier.ciencia-id3A12-B260-A36C
person.identifier.ciencia-id151E-1B5E-DAE5
person.identifier.orcid0000-0002-6212-3722
person.identifier.orcid0000-0003-0691-4308
person.identifier.orcid0000-0002-4761-614X
person.identifier.orcid0000-0003-2479-7846
person.identifier.ridK-8072-2014
person.identifier.ridL-2491-2014
person.identifier.scopus-author-id6603702602
person.identifier.scopus-author-id6507416937
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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