Browsing by Author "Rousselle, J.C."
Now showing 1 - 2 of 2
Results Per Page
Sort Options
- IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central IndiaPublication . Bansal, D.; Herbert, F.; Lim, P.; Deshpande, P.; Becavin, C.; Guiyedi, V.; de Maria, I.; Rousselle, J.C.; Namane, A.; Jain, R.; Cazenave, P.A.; Mishra, G.C.; Ferlini, C.; Fesel, C.; Benecke, A.; Pied, S.We investigated the significance of these self-reactive antibodies in clinically well-defined groups of P. falciparum infected patients manifesting mild malaria (MM), severe non-cerebral malaria (SM), or cerebral malaria (CM) and in control subjects from Gondia, a malaria epidemic site in central India using quantitative immunoprinting and multivariate statistical analyses. A two-fold complete-linkage hierarchical clustering allows classifying the different patient groups and to distinguish the CM from the others on the basis of their profile of IgG reactivity to brain proteins defined by PANAMA Blot. We identified beta tubulin III (TBB3) as a novel discriminant brain antigen in the prevalence of CM. In addition, circulating IgG from CM patients highly react with recombinant TBB3. Overall, correspondence analyses based on singular value decomposition show a strong correlation between IgG anti-TBB3 and elevated concentration of cluster-II cytokine (IFNγ, IL1β, TNFα, TGFβ) previously demonstrated to be a predictor of CM in the same population
- Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese childrenPublication . Guiyedi, V.; Chanseaud, Y.; Fesel, C.; Snounou, G.; Rousselle, J.C.; Lim, P.; Koko, J.; Namane, A.; Cazenave, P.A.; Kombila, M.; Pied, S.Hypergammaglobulinemia and polyclonal B-cell activation commonly occur in Plasmodium sp. infections. Some of the antibodies produced recognize self-components and are correlated with disease severity in P. falciparum malaria. However, it is not known whether some self-reactive antibodies produced during P. falciparum infection contribute to the events leading to cerebral malaria (CM). We show here a correlation between self-antibody responses to a human brain protein and high levels of circulating TNF alpha (TNFα), with the manifestation of CM in Gabonese children