Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children

Hypergammaglobulinemia and polyclonal B-cell activation commonly occur in Plasmodium sp. infections. Some of the antibodies produced recognize self-components and are correlated with disease severity in P. falciparum malaria. However, it is not known whether some self-reactive antibodies produced during P. falciparum infection contribute to the events leading to cerebral malaria (CM). We show here a correlation between self-antibody responses to a human brain protein and high levels of circulating TNF alpha (TNFα), with the manifestation of CM in Gabonese children

Keywords

Immunoglobulin G/immunology Malaria, Cerebral/immunology Malaria, Falciparum/immunology Spectrin/immunology

URI

http://hdl.handle.net/10400.7/214
http://dx.doi.org/10.1371/journal.pone.0000389

Citation

Guiyedi, V, Chanseaud, Y., Fesel C., Snounou G., Rousselle J.-C., Lim P., Koko J., Namane A., Cazenave P.-A., Kombila M., Pied S. (2007) “Self-reactivities to the non-erythroid Alpha Spectrin correlate with cerebral malaria in Gabonese children”. PLOS One. 2(4): e389