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- Placental Malaria: From Infection to MalfunctionPublication . de Moraes, Luciana Vieira; Penha-Gonçalves, CarlosMalaria during pregnancy is a major factor in infant morbidity and mortality. In this issue of Cell Host and Microbe, Conroy et al. (2013) propose that C5a, a product of complement cascade activation, counteracts the placental vascular remodeling response induced by Plasmodium infection and contributes to fetal growth restriction.