Lymphocyte Physiology

We dedicate most of our efforts to the understanding of the cellular and molecular regulation that ensure the production and maintenance of a healthy immune system. Autoimmunity and inflammatory immuno-pathologies result from misdirected and exacerbated immune responses, respectively. Several layers of regulation ensure that a healthy immune system discriminates self from non-self components, and, amongst the latter, innocuous commensals and food antigens from infectious agents. Similarly, a healthy immune system relies on robust regulatory mechanisms to return to equilibrium (homeostasis) after an immune challenge or other stresses.