Immune Regulation

The ultimate function of the immune system is to cooperate with other body systemsin order to maintain homeostasis within multi-cellular organisms.To perform such a task, cells and molecules of the immune system evolved to distinguish between 'self' and 'non-self' molecules. We are interested in better understanding the regulation that occurs inside the immune system, focusing our attention on a particular cell type called regulatory T cell. We combine classical cellular analyses with intravital imaging techniques to investigate the function of immune cells in tissues under various conditions of activation/in"ammation. To this aim, we developped surgical procedures and tools to perform these analyses using two-photon microscopy, which allows the observation of single-cell dynamics and cell interactions as well as their spatial localisation inside the organs.