NM- Artigos
URI permanente para esta coleção:
Navegar
Percorrer NM- Artigos por assunto "Cell cycle checkpoint"
A mostrar 1 - 1 de 1
Resultados por página
Opções de ordenação
- Modelling the onset of senescence at the G1/S cell cycle checkpointPublication . Mombach, José CM; Bugs, Cristhian A; Chaouiya, ClaudineDNA damage (single or double-strand breaks) triggers adapted cellular responses. These responses are elicited through signalling pathways, which activate cell cycle checkpoints and basically lead to three cellular fates: cycle arrest promoting DNA repair, senescence (permanent arrest) or cell death. Cellular senescence is known for having a tumour-suppressive function and its regulation arouses a growing scientific interest. Here, we advance a qualitative model covering DNA damage response pathways, focusing on G1/S checkpoint enforcement, supposedly more sensitive to arrest than G2/M checkpoint.