Modelling the onset of senescence at the G1/S cell cycle checkpoint

Mombach, José CM; Bugs, Cristhian A; Chaouiya, Claudine

http://hdl.handle.net/10400.7/339

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Autores

Mombach, José CM

Bugs, Cristhian A

Chaouiya, Claudine

Resumo(s)

DNA damage (single or double-strand breaks) triggers adapted cellular responses. These responses are elicited through signalling pathways, which activate cell cycle checkpoints and basically lead to three cellular fates: cycle arrest promoting DNA repair, senescence (permanent arrest) or cell death. Cellular senescence is known for having a tumour-suppressive function and its regulation arouses a growing scientific interest. Here, we advance a qualitative model covering DNA damage response pathways, focusing on G1/S checkpoint enforcement, supposedly more sensitive to arrest than G2/M checkpoint.

Palavras-chave

Signalling network Logical modelling Senescence DNA-damage Cell fate Cell cycle checkpoint

URI

http://hdl.handle.net/10400.7/339

Editora

BioMed Central

DOI

10.1186/1471-2164-15-S7-S7

Coleções

NM- Artigos

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