Modelling the onset of senescence at the G1/S cell cycle checkpoint

Mombach, José CM; Bugs, Cristhian A; Chaouiya, Claudine

http://hdl.handle.net/10400.7/339

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Authors

Mombach, José CM

Bugs, Cristhian A

Chaouiya, Claudine

Abstract(s)

DNA damage (single or double-strand breaks) triggers adapted cellular responses. These responses are elicited through signalling pathways, which activate cell cycle checkpoints and basically lead to three cellular fates: cycle arrest promoting DNA repair, senescence (permanent arrest) or cell death. Cellular senescence is known for having a tumour-suppressive function and its regulation arouses a growing scientific interest. Here, we advance a qualitative model covering DNA damage response pathways, focusing on G1/S checkpoint enforcement, supposedly more sensitive to arrest than G2/M checkpoint.