CONTROL OF ADAPTIVE IMMUNITY AGAINST PLASMODIUM INFECTION BY GUT FLORA

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Microbiota Control of Malaria Transmission

Publication . Soares, Miguel P.; Yilmaz, Bahtiyar

Stable mutualistic interactions between multicellular organisms and microbes are an evolutionarily conserved process with a major impact on host physiology and fitness. Humans establish such interactions with a consortium of microorganisms known as the microbiota. Despite the mutualistic nature of these interactions, some bacterial components of the human microbiota express immunogenic glycans that elicit glycan-specific antibody (Ab) responses. The ensuing circulating Abs are protective against infections by pathogens that express those glycans, as demonstrated for Plasmodium, the causative agent of malaria. Presumably, a similar protective Ab response acts against other vector-borne diseases.

2016-02Journal article

Open access