Microbiota Control of Malaria Transmission

Soares, Miguel P.; Yilmaz, Bahtiyar

http://hdl.handle.net/10400.7/768

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Authors

Soares, Miguel P.

Yilmaz, Bahtiyar

Abstract(s)

Stable mutualistic interactions between multicellular organisms and microbes are an evolutionarily conserved process with a major impact on host physiology and fitness. Humans establish such interactions with a consortium of microorganisms known as the microbiota. Despite the mutualistic nature of these interactions, some bacterial components of the human microbiota express immunogenic glycans that elicit glycan-specific antibody (Ab) responses. The ensuing circulating Abs are protective against infections by pathogens that express those glycans, as demonstrated for Plasmodium, the causative agent of malaria. Presumably, a similar protective Ab response acts against other vector-borne diseases.

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Keywords

Antibodies Biological Evolution Host-Pathogen Interactions Humans Intestines Malaria, Falciparum Microbiota Plasmodium falciparum Polysaccharides Protozoan Vaccines

URI

http://hdl.handle.net/10400.7/768

Citation

Miguel P. Soares, Bahtiyar Yilmaz, Microbiota Control of Malaria Transmission, Trends in Parasitology, Volume 32, Issue 2, 2016, Pages 120-130, ISSN 1471-4922, http://dx.doi.org/10.1016/j.pt.2015.11.004. (http://www.sciencedirect.com/science/article/pii/S147149221500238X)