Insulin Clearance (Dys)Regulation: clarifying the mist.

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How Inflammation Impinges on NAFLD: A Role for Kupffer Cells

Publication . Duarte, Nádia; Coelho, Inês C.; Patarrão, Rita S.; Almeida, Joana I.; Penha-Gonçalves, Carlos; Macedo, M. Paula

Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps of NAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.

2015-03-05Journal article

Open access

Funding agency

Fundação para a Ciência e a Tecnologia

Funding programme

3599-PPCDT

Funding Award Number

PTDC/DTP-EPI/0207/2012