The reward value of sucrose in leptin-deficient obese mice

Domingos, Ana I.; Vaynshteyn, Jake; Sordillo, Aylesse; Friedman, Jeffrey M.

Publication

The reward value of sucrose in leptin-deficient obese mice

2013-12-05Journal article

dc.contributor.author	Domingos, Ana I.
dc.contributor.author	Vaynshteyn, Jake
dc.contributor.author	Sordillo, Aylesse
dc.contributor.author	Friedman, Jeffrey M.
dc.date.accessioned	2016-05-05T09:05:03Z
dc.date.available	2016-05-05T09:05:03Z
dc.date.issued	2013-12-05
dc.description.abstract	Leptin-deficient patients report higher "liking" ratings for food, and leptin replacement therapy normalizes these ratings even before weight loss is achieved. Since animals cannot report their ratings, we studied the relationship between leptin and food reward in leptin-deficient ob/ob mice using a optogenetic assay that quantifies the reward value of sucrose. In this assay, mice chose between one sipper dispensing the artificial sweetener sucralose coupled to optogenetic activation of dopaminergic (DA) neurons, and another sipper dispensing sucrose. We found that the reward value of sucrose was high under a state of leptin deficiency, as well as at a dose of leptin that does not suppress food intake (12.5 ng/h). Treatment with higher doses of leptin decreased the reward value of sucrose before weight loss was achieved (100 ng/h), as seen in leptin-deficient patients. These results phenocopy in mice the behavior of leptin-deficient patients.	pt_PT
dc.description.sponsorship	JPB Foundation; The Klarman Family Foundation for Eating Disorders; The Rockefeller Foundation; Gulbenkian Foundation; FCT.	pt_PT
dc.identifier.citation	Ana I. Domingos, Jake Vaynshteyn, Aylesse Sordillo, Jeffrey M. Friedman, The reward value of sucrose in leptin-deficient obese mice, Molecular Metabolism, Volume 3, Issue 1, February 2014, Pages 73-80, ISSN 2212-8778, http://dx.doi.org/10.1016/j.molmet.2013.10.007. (http://www.sciencedirect.com/science/article/pii/S2212877813001051) Keywords: Sucrose; Food preference; Reward value; Optogenetics; Leptin; Obesity	pt_PT
dc.identifier.doi	10.1016/j.molmet.2013.10.007	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/596
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Elsivier Science BV	pt_PT
dc.relation.publisherversion	http://www.sciencedirect.com/science/article/pii/S2212877813001051	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Sucrose	pt_PT
dc.subject	Food preference	pt_PT
dc.subject	Reward value	pt_PT
dc.subject	Optogenetics	pt_PT
dc.subject	Leptin	pt_PT
dc.subject	Obesity	pt_PT
dc.title	The reward value of sucrose in leptin-deficient obese mice	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	80	pt_PT
oaire.citation.issue	1	pt_PT
oaire.citation.startPage	73	pt_PT
oaire.citation.title	Molecular Metabolism	pt_PT
oaire.citation.volume	3	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT